摘要
目的探讨普瑞巴林联合甲钴胺对带状疱疹患者神经病理性疼痛程度及不良反应的影响,为该疗法的临床应用提供依据。方法回顾性分析2019年2月~2020年6月盘锦辽油宝石花医院收治的82例带状疱疹患者的临床资料,按照不同治疗方法分为观察组与对照组,每组各41例。对照组患者接受甲钴胺治疗,观察组患者接受甲钴胺联合普瑞巴林治疗。比较两组患者治疗前、治疗2周后的神经病理性疼痛程度[视觉模拟量表(VAS)评分]、炎症指标[白细胞介素(IL)-6、IL-8、C-反应蛋白(CRP)]水平及两组治疗期间的不良反应(困倦乏力、头晕、恶心)。结果治疗前两组患者的VAS评分比较,差异无统计学意义(P>0.05);治疗后两组患者的VAS评分低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者的VAS评分低于对照组,差异有统计学意义(P<0.05)。治疗前两组患者的IL-6、IL-8、CRP水平比较,差异无统计学意义(P>0.05);治疗后两组患者的IL-6、IL-8、CRP水平低于治疗前,差异有统计学意义(P<0.05);治疗后,观察组患者的IL-6、IL-8、CRP水平低于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论普瑞巴林联合甲钴胺治疗带状疱疹效果显著,可有效降低神经病理性疼痛程度,改善患者的炎症反应,且用药安全性较高。
Objective To investigate the effect of Pregabalin combined with Mecobalamin on neuropathic pain and adverse reactions in patients with herpes zoster,and to provide a basis for the clinical application of this therapy.Methods The clinical data of 82 patients with herpes zoster admitted to Liaoyou Baoshihua Hospital in Panjin from February 2019 to June 2020 were retrospectively analyzed.According to different treatment methods,they were divided into the observation group and the control group,with 41 cases in each group.The control group was treated with Mecobalamine,and the observation group was treated with Mecobalamine combined with Pregabalin.Neuropathic pain(visual analogue scale[VAS]score),inflammatory markers(interleukin[IL]-6,IL-8,C-reactive protein[CRP])levels before and 2 weeks after treatment,and adverse reactions(sleepiness,fatigue,dizziness,nausea)during treatment were compared between the two groups.Results There was no significant difference in VAS score between the two groups before treatment(P>0.05).The VAS scores in the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the VAS score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in the levels of IL-6,IL-8 and CRP between the two groups(P>0.05).After treatment,the levels of IL-6,IL-8 and CRP in the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the levels of IL-6,IL-8 and CRP in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Pregabalin combined with Mecobalamin has a significant effect on the treatment of herpes zoster,which can effectively reduce the degree of neuropathic pain and improve the inflammatory response of patients,and the medication is safer.
作者
高俊明
赵敏
王冬梅
左旭
王琦
GAO Jun-ming;ZHAO Min;WANG Dong-mei;ZUO Xu;WANG Qi(Department of Dermatology,Liaoyou Baoshihua Hospital of Panjin City,Liaoning Province,Panjin124010,China)
出处
《中国当代医药》
CAS
2021年第8期48-51,共4页
China Modern Medicine
基金
辽宁省医学科技攻关计划项目(2019-3908)。
