摘要
目的:探讨替米沙坦联合比索洛尔治疗高血压心力衰竭的临床效果和安全性。方法:选取2018年3月—2020年3月本院收治的86例高血压心力衰竭患者,按随机数字表法分为两组,各43例。两组均予以纠正水电解质、强心、利尿等常规治疗,并叮嘱低脂、低盐饮食,两组均给予比索洛尔治疗,初始口服2.5 mg/次,1次/d,后期依据病情调整剂量,最多增至10 mg/次,1次/d;观察组在对照组基础上加用替米沙坦治疗,初始剂量口服40 mg/d,后期增至80 mg/d,均1次/d。比较两组血压水平及6 min步行距离、心功能指标、不良反应发生情况。结果:治疗前,两组血压水平及6 mim步行距离比较,无统计学差异(P>0.05);治疗后,两组血压水平低于治疗前,6 min步行距离长于治疗前,且观察组血压低于对照组,6 min步行距离长于对照组,差异有统计学意义(P<0.05)。治疗前,两组心功能指标比较,无统计学差异(P>0.05);治疗后,两组心功能优于治疗前,且观察组左室射血分数(LVEF)高于对照组,左室舒张末内径(LVEDD)和左室收缩末内径(LVESD)低于对照组,差异有统计学意义(P<0.05)。两组均无严重不良反应发生,对症处理后未影响治疗。结论:替米沙坦联合比索洛尔治疗可稳定高血压心力衰竭患者血压水平,促进心功能恢复,延长6 min步行距离,安全可靠。
Objective:To evaluate the clinical efficacy and safety of telmisartan combined with bisoprolol in the treatment of hypertensive heart failure.Methods:A total of 86 patients with hypertension heart failure admitted to our hospital from March 2018 to March 2020 were selected and divided into two groups according to the random number table method,with 43 cases in each group.Both groups were given conventional treatment,such as correct water and electrolyte,cariostatic and diuretic therapy,and were told to eat a low-fat and low-salt diet.The control group was additionally treated with bisoprolol,and the initial oral administration was 2.5 mg/time,once a day.The later dose was adjusted according to the condition,up to 10 mg/time,once a day.The observation group was additionally treated with telmisartan on the basis of the above,and the initial dose was 40 mg/d orally.The later dose of telmisartan was increased to 80 mg/d once a day.Blood pressure,6-min walking distance,cardiac function indexes,and the incidence of adverse reactions were compared between the two groups.Results:Before treatment,there were no significant differences in blood pressure and 6-min walking distance between the two groups(P>0.05).After treatment,the blood pressure levels of the two groups were lower than those before treatment,and the 6-min walking distances were longer than those before treatment.The differences were statistically significant(P<0.05).Moreover,before treatment,there was no statistical difference in heart function indexes between the two groups(P>0.05).After treatment,the heart function in both groups was better than before treatment,and LVEF in the observation group was higher than that in the control group,while LVEDD and LVESD were lower than those in the control group.The differences were statistically significant(P>0.05).No severe adverse reactions occurred in both groups,and the symptomatic treatment did not affect the treatment.Conclusion:Telmisartan combined with bisoprolol can stabilize blood pressure level,promote cardiac function recovery,prolong 6-min walking distance in patients with hypertensive heart failure,which is safe and reliable.
作者
王磊
Wang Lei(Jiaozuo Fifth People's Hospital,Henan 454001)
出处
《天津药学》
2021年第1期50-52,共3页
Tianjin Pharmacy
关键词
高血压
心力衰竭
替米沙坦
比索洛尔
心功能
不良反应
hypertension
heart failure
telmisartan
bisoprolol
cardiac function
adverse reactions
