摘要
该研究以高尿酸血症大鼠模型为对象,来评价扁舵鲣鱼低聚肽(Auxis thazard oligopeptide,ATO)降尿酸功效。结果表明,通过对比模型组、ATO 1.6 g/kg、2.4 g/kg剂量组,发现脏器系数并不存在显著差异。血清黄嘌呤氧化酶(xan-thine oxidase,XOD)的变化趋势为先降后升再缓降,据此可以确定,短时间内肝脏中XOD活性能明显降低。对比模型组可以发现,血清尿素氮、血肌酐指标有所下降,ATO 2.4 g/kg剂量组最为明显,血尿酸含量明显下降,差异有统计学意义(P<0.05)。各试验组的尿酸浓度和尿酸排泄量相比正常组也有明显降低(P<0.05)。依据组织病理学结果可知,通过ATO的应用,能够保护高尿酸血症大鼠的肾脏,但剂效关系尚不明显;尿酸生成因尿酸盐沉积的减少而降低,因而ATO具有一定的降尿酸功效,并且不会产生过多的毒副作用。
Hyperuricemia rat model was used to evaluate Auxis thazard oligopeptide(ATO)on lowering uric acid.The results showed that there was no significant difference in organ coefficients between 1.6 g/kg and 2.4 g/kg ATO groups compared with model group.Moreover,serum XOD showed a trend of decreasing first and then increasing,finally declining slowly,which indicated that XOD activity in the liver was significantly decreased in a short term.Besides,serum urea nitrogen and serum creatinine showed a downward trend,the blood uric acid content of 2.4 g/kg ATO group decreased significantly(P<0.05).The uric acid concentration and uric acid excretion in each test group were also significantly lower than those in the normal group(P<0.05).Futhermore,histopathological results showed that ATO had a certain protective effect on the kidney of hyperuricemia rats.However,the dose-effect relationship was not significant.Less urate deposition indicated a decrease in uric acid production to some extent.Therefore,ATO has a certain uric acid lowering effect even though with a little toxic side effects.
作者
吉薇
吉宏武
JI Wei;JI Hongwu(College of Biology and Food Engineering,Guangdong University of Education,Guangzhou 510303,China;College of Food Science and Technology,Guangdong Ocean University,Zhanjiang 524088,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2021年第6期62-67,共6页
Food and Fermentation Industries
基金
国家重点研发计划(2019YFD0902000)
国家自然科学基金青年基金(31801614)。
