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肺移植后急性肾损伤及肾脏替代治疗

Acute kidney injury after lung transplantation and its renal replacement therapy
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摘要 肺移植后急性肾损伤(AKI)是肺移植后常见并发症,肺移植过程中全身血流动力学不稳定,体外膜肺氧合(ECMO)支持及术后免疫抑制药物的应用等均是导致AKI的原因,现阶段较高的发病率显著影响肺移植患者的生存和预后。因此,早期发现并启动治疗对肺移植后AKI患者意义重大。目前对于AKI的诊断标准主要围绕血肌酐及尿量,并不能及早诊断,新型肾损伤标志物中性粒细胞明胶酶相关载脂蛋白(NGAL)、肾脏损伤分子-1(KIM-1)、肝脏型脂肪酸结合蛋白(LFAB-P)、尿液金属蛋白酶-2组织抑制剂(TIMP-2)和胰岛素样生长因子结合蛋白7(IGFBP-7)等可早期识别AKI,有助于早期诊断及治疗。对于肺移植后AKI患者,应加强早期诊断、早期干预,以期改善肺移植后AKI患者的结局。
作者 焦圆圆 陆海涛 李文歌 Jiao Yuanyuan;Lu Haitao;Li Wenge
出处 《临床内科杂志》 CAS 2021年第3期149-151,共3页 Journal of Clinical Internal Medicine
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