摘要
目的:探讨学龄期儿童认知功能事件相关电位(event-related potentials,ERPs)P300的发展特征。方法:180例7~12岁学龄期儿童按年龄分为7~8岁组(n=48)、9~10岁组(n=44)和11~12岁组(n=48),并进行Oddball任务检测,采用SPSS 21.0软件对行为学结果及P300的亚成分P3a、P3b波幅、潜伏期进行分析。结果:(1)7~8岁组、9~10岁组、11~12岁组儿童击中数[49(47.25,50)个,50(49,50)个,50(50,50)个]、正确反应时[(533.37±56.94)ms,(486.91±61.12)ms,(411.55±51.97)ms]、虚报数[2(1,4)个,2(1,3)个,1(0,2)个]差异均有统计学意义(F值/χ2=20.635,54.477,13.169,均P<0.01)。(2)P3a波幅的年龄主效应(F=3.884,P=0.023)、年龄×刺激类型交互效应(F=3.314,P=0.038)显著,刺激类型主效应不显著(F=0.111,P=0.740)。11~12岁组靶P3a波幅[(11.02±6.00)μV]较7~8岁组[(7.36±4.48)μV]与9~10岁组[(7.76±5.17)μV]增高,差异有统计学意义(均P<0.05)。而P3a潜伏期、P3b波幅与潜伏期分组×条件交互效应均不显著(P>0.05)。结论:P3a可能是学龄期儿童认知功能的敏感监测指标,11~12岁是儿童注意定向、选择能力发展的关键时期,可能与脑网络发育程度有关。
Objective To investigate the characteristics of event-related potentials(ERPs)P300 in the development of attention cognitive function of school-age children.Methods A total of 180 school-age children were divided into 3 groups according to their ages(7-8 years old group with 48 cases,9-10 years old group with 44 cases and 11-12 years old group with 48 cases).All of the participants completed an Oddball task,and their behavioral data,P3a and P3b components of ERPs were analyzed by SPSS 21.0.Results(1)The differences of hit numbers(49(47.25,50),50(49,50),50(50,50)),correct reaction time((533.37±56.94)ms,(486.91±61.12)ms,(411.55±51.97)ms),and Omission errors(2(1,4),2(1,3),1(0,2))among the three groups were statistically significant(F/χ2=20.635,54.477,13.169,all P<0.01).(2)There was a main effect of age(F=3.884,P=0.023)and an interaction effect between age and condition(F=3.314,P=0.038)on the amplitude of P3a,while the main effect of condition was not significant(F=0.111,P=0.740).The amplitude of P3a component in 11-12 years old group((11.02±6.00)μV)was significantly larger than that of 7-8 years old group((7.36±4.48)μV)and 9-10 years old group((7.76±5.17)μV,both P<0.05).However,there was no significant interaction effect between age and condition on P3a latency,P3b amplitude and latency(P>0.05).Conclusion P3a may be a sensitive indicator of cognitive function in school-age children,and the age of 11-12 years old is a sensitive period for the development of children's attention orientation and selection ability,which may be related to the development of brain network.
作者
张毅力
任艳玲
蔡婧
陈纡
马岭
陈芋圻
高鹏
王苏弘
Zhang Yili;Ren Yanling;Cai Jing;Chen Yu;Ma Ling;Chen Yuqi;Gao Peng;Wang Suhong(Department of Clinical Psychology,the Third Affiliated Hospital of Soochow University,Changzhou 213003,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2021年第2期145-149,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(81101018)
江苏省科学技术厅第五期"333工程"科研项目自主计划(RBA201711)
常州市科技局应用基础研究计划(CJ20160458)。
