摘要
目的:评价4DCT检测75岁及以上食管癌患者放疗前后的肺通气功能。方法:纳入31例符合条件的75岁及以上高龄食管癌患者。4DCT扫描图像经过形变配准后进行几何二等分。制定3个肺通气功能分析指标:上下肺通气比值,左右肺通气比值和前后肺通气比值。结果:伴有慢性阻塞性肺疾病(COPD)组与无COPD组的上下肺通气比值差异有统计学意义(P<0.05),前后肺通气比值及左右肺通气比值未见明显差异。在75~80岁组与≥80岁组只发现上下肺通气比值差异有统计学意义(P<0.05)。放疗后在COPD组与无COPD组中发现上下肺通气比值(P<0.05)及前后肺通气比值(P<0.05)均有明显差异。放疗后75~80岁组与≥80岁组的上下肺通气比值有统计学差异(P<0.05)。放疗期间同步化疗组与未同步化疗组在肺通气功能上未见明显差别。结论:应用4DCT扫描可区别放疗前后的肺通气功能变化,为早期临床干预提供可能。
Objective To use four-dimensional computed tomography(4DCT)for evaluating the pulmonary ventilation in esophageal cancer patients aged 75 years and over.Methods Thirty-one esophageal cancer patients aged 75 years and over were enrolled in the study.4DCT images were dichotomized by geometry after deformation.The pulmonary ventilation function was evaluated by 3 indexes,namely superior-inferior pulmonary ventilation ratio,left-right pulmonary ventilation ratio and anterior-posterior pulmonary ventilation ratio.Results There was significant difference between chronic obstructive pulmonary disease(COPD)group and non-COPD group in superior-inferior pulmonary ventilation ratio(P<0.05),but not in anterior-posterior pulmonary ventilation ratio and left-right pulmonary ventilation ratio.Moreover,significant difference was only found in superior-inferior pulmonary ventilation ratio between patients aged 75-80 years and those aged 80 years and over(P<0.05).After radiotherapy,there were significant differences between COPD group and non-COPD group in superiorinferior pulmonary ventilation ratio(P<0.05)and anterior-posterior pulmonary ventilation ratio(P<0.05),and the superiorinferior pulmonary ventilation ratio in patients aged 75-80 years was significantly different from that in those aged 80 years and over(P<0.05).During radiotherapy,the pulmonary ventilation function in chemoradiotherapy group was similar to that in non-concurrent chemotherapy group.Conclusion 4DCT can be used to detect the variations of pulmonary ventilation function before and after radiotherapy,providing the possibility for the early clinical intervention.
作者
沈建军
牛维纳
闫冰
余枭
解远
SHEN Jianjun;NIU Weina;YAN Bing;YU Xiao;XIE Yuan(Department of Radiation Oncology,the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital),Hefei 230001,China)
出处
《中国医学物理学杂志》
CSCD
2021年第3期277-280,共4页
Chinese Journal of Medical Physics
基金
中央高校基本科研业务费专项(WK9110000106)。
关键词
食管癌
四维计算机断层扫描
放射治疗
肺功能
esophageal cancer
four-dimensional computed tomography
radiotherapy
pulmonary function
