摘要
胆汁淤积症是指在胆管细胞和(或)肝细胞水平上胆汁形成和(或)流动障碍,是肝脏疾病的常见并发症之一。大量胆汁酸淤积于肝脏可导致肝纤维化和肝细胞损伤,甚至发生肝衰竭。新生儿尤其是早产儿在出生时或出生后会受到窒息、感染、出血或其他创伤应激等许多高危因素的影响,而且喂养不耐受的发生率较高,需要肠外营养支持,故易导致肠道菌群紊乱,并增加新生儿胆汁淤积的发生率。因此,明确新生儿胆汁淤积的病因及发病机制对疾病的诊断、治疗和患儿的预后均有重要意义。
Cholestasis is a common complication of liver disease,which refers to forms/flows disorder on the liver cell/bile duct cell level.Massive cholestasis in the liver can lead to liver fibrosis and hepatocyte damage,and even liver failure.The neonates,especially the premature babies before or after birth not only often suffer suffocation,infection,hemorrhage,or other traumatic stress,but also have high incidence of feeding intolerance,needing the parenteral nutrition,which may easily result in intestinal flora disorder,and the increase of incidence of neonatal cholestasis.Therefore,exploring the etiology and pathogenesis of neonatal cholestasis is of great significance for the diagnosis,treatment and prognosis.
作者
伍高红
陈嘉敏
黄辉文
朱雪萍
WU Gaohong;CHEN Jiamin;HUANG Huiwen;ZHU Xueping(Department of Neonatology,Zhuhai Women and Children′s Hospital,Zhuhai 519001,China;Department of Neonatology,Children′s Hospital of Soochow University,Soochow 215025,China)
出处
《医学综述》
CAS
2021年第6期1066-1073,共8页
Medical Recapitulate
基金
国家自然科学基金(81771626,81971423)
江苏省妇幼健康重点人才项目(FRC201731)。
