摘要
目的探讨视网膜分支静脉阻塞(BRVO)继发黄斑水肿(ME)病眼单次康柏西普注射后黄斑区视网膜血流参数的变化。方法选取2019年6—11月安徽省第二人民医院收治的BRVO继发ME的病人31例31眼,所有病眼均接受抗VEGF治疗,药物为康柏西普。注射前和注射后1月,所有病人均接受最佳矫正视力(BCVA)和OCTA检查。其中,软件自动测量治疗前后中心凹视网膜厚度(CMT)、黄斑中心凹无血管面积(FAZ)、浅层视网膜毛细血管网血管长度密度(VLT)和灌注密度(PD)的变化。采用配对t检验法分析治疗前后病眼各项资料差异。结果与康柏西普注射1月后比较,CMT由治疗前(474.2±95.1)μm降低至(320.3±131.2)μm,差异有统计学意义(t=10.725,P=0.000);BCVA由治疗前(54.94±16.87)个提升至(66.78±19.21)个,差异有统计学意义(t=-11.591,P=0.015);黄斑区FAZ较治疗前差异无统计学意义(t=0.967,P>0.05);黄斑区不同区域浅层视网膜毛细血管网血管长度密度(VLT)及灌注密度(PD)较治疗前均差异无统计学意义(P>0.05)。结论单次玻璃体腔注射康柏西普后,BRVO继发ME病眼短期内CMT明显下降,BCVA显著提高,且对黄斑区FAZ及视网膜浅层毛细管的视网膜血管密度无明显影响。
Objective To investigate the changes of retinal blood flow parameters in macular area after single injection of Conbercept in patients with macular edema(ME)secondary to BRVO.Methods Thirty-one patients with ME secondary to BRVO in Anhui NO.2 Provincial People's Hospital from June 2019 to November 2019 were selected.All the patients received anti-VEGF treatment,and the drug was Conbercept.The best corrected visual acuity(BCVA)and OCTA were performed before the injection and one month after the injection.Among them,the software automatically measured changes in foveal retinal thickness(CMT),foveal avascular area(FAZ),superficial retinal capillary network vessel length density(VLT)and perfusion density(PD)before and after treatment.Paired ttest was used to analyze the differences in various data before and after treatment.Results After treatment for 1 month,CMT decreased from(474.2±95.1)μm before treatment to(320.3±131.2)μm,and the difference was statistically significant(t=10.725,P=0.000).BCVA increased from(54.94±16.87)before treatment to(66.78±19.21),and the difference was statistically significant(t=-11.591,P=0.015).FAZ in the macular area was not significantly different from that before treatment(t=0.967,P>0.05).Shallow retinal capillary network vascular length density(VLT)and perfusion density(PD)in different regions of the macular area,there was no significant change compared with before treatment(P>0.05).Conclusion After a single intravitreal injection of Conbercept,the CMT in BRVO secondary ME patients is significantly decreased,and the BCVA is significantly improved in a short period of time,and the retinal vascular density in macular FAZ and superficial capillary of retina is not significantly affected.
作者
乔灵飞
姜波
史春生
QIAO Lingfei;JIANG Bo;SHI Chunsheng(Department of Ophthalmolohy,Anhui NO.2Provincial People's Hospital,Hefei,Anhui 230041,China)
出处
《安徽医药》
CAS
2021年第4期818-820,I0002,共4页
Anhui Medical and Pharmaceutical Journal
基金
安徽省卫生计生委科研计划项目(2018SEYL025)
安徽省高校自然科学研究重点项目(KJ2019A1097)
安徽省高校自然科学研究一般项目(12925KJ2018B11)。
