摘要
目的探讨慢性心力衰竭(CHF)患者血清HE4水平与其心肾功能的关系。方法选取2015年1月~2018年5月我院收治的CHF患者53例为观察组,另选取同期健康体检者50名作为对照组,比较两组临床指标(LVEF、NT-BNP、cTnT、HE4)及观察组不同心功能分级CHF患者及不同肾损伤CHF患者各指标变化,采用Spearman相关性分析HE4与NYHA心功能分级、GFR的相关性。结果观察组LVEF、NT-BNP、cTnT、HE4均高于对照组,差异有统计学意义(P<0.05)。不同心功能分级间LVEF、NT-BNP、cTnT、HE4比较,差异有统计学意义(P<0.05),其中CHF患者外周血中HE4、NT-BNP、cTnT随着心功能的下降而升高,LVEF随着心功能的下降而减小;不同肾损伤CHF患者NT-BNP、cTnT、HE4比较,差异有统计学意义(P<0.05),不同肾损伤CHF患者LVEF比较,差异无统计学意义(P>0.05),其中HE4、cTnT随着GFR下降而升高,但GFR正常者与GFR轻度下降者NT-BNP水平无差异。Spearman相关性分析显示,HE4与NYHA、NT-BNP、cTnT呈正相关(r=0.341、0.381、0.438,P<0.05),与GFR呈负相关(r=-0.221,P<0.05),而与LVEF无相关性(r=-0.167,P>0.05)。结论血清HE4水平可以较好的反映CHF患者心肾功能的变化,可为CHF患者心肾功能监测提供参考依据。
Objective To investigate the relationship between the serum HE4 level and the heart and kidney function in patients with chronic heart failure(CHF).Methods A total of 53 CHF patients admitted to our hospital from January 2015 to May 2018 were selected as the observation group,and 50 healthy subjects were selected as the control group during the same period.To compare the clinical indicators(LVEF,NT-BNP,cTnT,HE4)of the two groups and the changes of indicators in the observation group of CHF patients with different cardiac function grades and CHF patients with different kidney injury,Spearman correlation was used to analyze the correlation between HE4 and NYHA cardiac function classification and GFR.Results LVEF,NT-BNP,cTnT and HE4 in the observation group were higher than those in the control group,the difference was statistically significant(P<0.05).Comparison of LVEF,NT-BNP,cTnT,HE4 among different cardiac function grades,the difference was statistically significant(P<0.05),Among them,HE4,NT-BNP,cTnT in peripheral blood of CHF patients increased with the decline of heart function,and LVEF decreased with the decline of heart function;comparison of NT-BNP,cTnT,HE4 in CHF patients with different kidney injury,the difference was statistically significant(P<0.05),there was no statistically significant difference in LVEF of CHF patients with different kidney injury(P>0.05).Among them,HE4 and cTnT increased with the decrease of GFR,but there was no difference in NT-BNP levels between those with normal GFR and those with mildly decreased GFR.Spearman correlation analysis showed that HE4 was positively correlated with NYHA,NT-BNP,and cTnT(r=0.341,0.381,0.438,P<0.05).There was a negative correlation with GFR(r=-0.221,P<0.05),but no correlation with LVEF(r=-0.167,P>0.05).Conclusion Serum HE4 level can better reflect the changes of heart and kidney function in CHF patients,and can provide a reference for the monitoring of heart and kidney function in CHF patients.
作者
楚金申
汤金萍
曹俊达
王路
邓林锋
王乐娴
刘晓峰
陈雪礼
CHU Jin-shen;TANG Jin-ping;CAO Jun-da;WANG Lu;DENG Lin-feng;WANG Le-xian;LIU Xiao-feng;CHEN Xue-li(Department of Laboratory Medicine,First People's Hospital of Jiujiang City,Jiujiang 332000,Jiangxi,China)
出处
《医学信息》
2021年第6期119-121,共3页
Journal of Medical Information
基金
江西省卫生计生委科技计划项目(编号:20172204)。
关键词
慢性心力衰竭
人类附睾蛋白4
心功能
肾功能
Chronic heart failure
Human epididymal protein 4
Heart function
Kidney function
