摘要
目的:研究苏州市吴江区40岁以上人群骨密度(bone mineral density,BMD)与血清钙(Ca)磷(P)代谢、维生素D及骨代谢间相关性。方法:采用多阶段分层随机抽样方法,选取2018年3—7月吴江区社区40岁以上人群骨质疏松症调查数据。采取双能X线吸收法(DXA)骨密度仪进行腰椎正位(L_(1-4)和L_(2-4))和股骨近端(股骨颈、大转子和全髋骨)BMD的测定。结果:本调查对象217例中男82例,女135例;平均年龄(57.03±10.43)岁。各部位BMD水平男女间差异均具有统计学意义(P<0.01)。单因素分析显示,性别、年龄、体质量指数(BMI)、P、碱性磷酸酶(ALP)、β-胶原降解产物(β-CTX)、总Ⅰ型胶原氨基端前肽(PINP)在各部位BMD差异均有统计学意义(P<0.01),25羟基维生素D[25(OH)D 3]仅在大转子BMD、全髋BMD差异有统计学意义(P<0.05)。在控制性别、年龄、BMI后,Ca、25(OH)D 3在各部位BMD差异均无统计学意义,而血清P与L_(1-4)、L_(2-4)BMD仅在0.05水平上相关,差异具有统计学意义。多元逐步回归分析结果显示,高龄、女性是BMD的危险因素,BMI与各部位BMD呈正相关(均β>0,P<0.05),P与股骨颈(β=-0.158)、大转子(β=-0.158)、全髋(β=-0.158)BMD呈负相关(P<0.05)。结论:吴江区40岁以上人群BMD与相关血生化、骨代谢指标具有显著相关性,血清P与股骨颈、大转子、全髋BMD呈负相关,PINP与各部位BMD值均呈负相关。
Objective:To study the correlation between bone mineral density(BMD)and serum calcium(Ca)phosphorus(P),vitamin D and bone metabolism index(BMI)in people over 40 years old in Wujiang District,Suzhou,Jiangsu.Methods:Multi-stage stratified random sampling method was used to select osteoporosis from March 2018 to July 2018 in Wujiang community.The BMD of lumbar spine(L _(1-4) and L _(2-4))and proximal femur(femoral neck,trochanter and total hip)were measured by dual energy X-ray absorptiometry(DXA).Results:The 217 subjects consisted of 82 males and 135 females,with an average age of(57.03±10.43)years.The difference of BMD level in different parts was statistically significant(P<0.01).Univariate analysis showed that sex,age,BMI,P,ALP,β-CTX,PINP were significantly correlated with BMD of all parts(P<0.01),25(OH)D 3 was only significantly correlated with BMD of trochanter and total hip(P<0.05).After controlling gender,age and BMI,there was no significant correlation between Ca,25(OH)D 3 and BMD of all parts,while serum P was only correlated with L_(1-4) and L_(2-4) at 0.05 level,the results showed statistically significant.The results of multiple stepwise regression analysis showed that being old and female were risk factors of BMD,BMI and BMD of all parts were positively correlated(allβ>0,P<0.05).P was negatively correlated with BMD of femoral neck(β=-0.158),trochanter(β=-0.158)and total hip(β=-0.158),and all the results were statistically significant(P<0.05).Conclusion:The correlation among BMD,serology and bone metabolism indexes is statistically significant.Serum P was negatively correlated with BMD of Femoral neck,Trochanter and Total hip,and there was a negative correlation between PINP and BMD.
作者
杨梅
沈红宇
沈建新
许锬
薛爱龙
沈红梅
张荣艳
姚小燕
俞哲宇
沈霞
YANG Mei;SHEN Hongyu;SHEN Jianxin;XU Tan;XUE Ailong;SHEN Hongmei;ZHANG Rongyan;YAO Xiaoyan;YU Zheyu;SHEN Xia(Wujiang District Center for Disease Control and Prevention,Suzhou 215200,China;School of Public Health,Medical Department of Soochow University/Key Laboratory of Geriatric Disease Prevention and Translational Medicine of Jiangsu Province,Suzhou 215123,China)
出处
《东南大学学报（医学版）》
CAS
2021年第1期22-26,共5页
Journal of Southeast University(Medical Science Edition)
基金
2018年度苏州大学高校省级重点实验室开放课题(KJS1860)。
关键词
骨质疏松
骨密度
骨代谢
吴江
osteoporosis
bone mineral density
bone metabolism
Wujiang
