摘要
高血压是目前常见的心血管疾病之一,具有发病率高,但治疗率与控制率相对较低的特点,随着网络药理学的逐渐发展,其"多成分、多途径、多靶点"协同作用的特点已被广泛应用于指导高血压病的治疗。通过对75篇文献的分析,对治疗高血压病的中药复方研究进展进行综述,阐释经典方剂与现代方剂中复方各药物活性、药物作用靶点、生物过程和通路分析等方面,并提出部分网络药理学在中药复方研究领域中存在的问题与展望。
Hypertension is one of the common cardiovascular diseases,with high incidence and relatively low treatment and control rates.With the rise of network pharmacology,the characteristics of its"multi-component,multi-channel,multi-target"synergistic effect are consistent with the overall view of traditional Chinese medicine and syndrome differentiation principles and have been widely used to guide the treatment of hypertension.This paper reviewed the research progress of traditional Chinese medicine(TCM)compound prescriptions for hypertension through the analysis of 75 articles,explained the aspects such as the activity,target,biological process and pathway analysis of TCM classical and modern compound prescriptions,and put forward the existing problems and prospects of part of network pharmacology in the research field of TCM compound prescriptions.
作者
杨长睿
焦华琛
李运伦
薛一涛
YANG Changrui;JIAO Huachen;LI Yunlun;XUE Yitao(Shandong University of Traditional Chinese Medicine,Jinan 250355,Shandong,China;Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250014,Shandong,China)
出处
《中华中医药学刊》
CAS
北大核心
2021年第2期72-77,共6页
Chinese Archives of Traditional Chinese Medicine
基金
国家临床研究基地二期建设项目(20081126)
山东省卫生与健康委员会中西医结合防治常见病多发病诊疗项目(2019-11)
薛一涛山东省名老中医药专家传承工作室(201992)
山东省泰山学者建设工程专项基金项目(201802)
济南市科技发展计划(201907044)。
关键词
网络药理学
高血压
中药复方
药物活性研究
network pharmacology
hypertension
traditional Chinese medicine compound
drug activity research
