摘要
疼痛是机体在遭受到某些伤害刺激后产生的一种不愉快的防御性反应,口腔科常见的诱发口腔颌面部疼痛的疾病有:牙髓炎、三叉神经痛、颌面部良恶性肿瘤、颞下颌关节紊乱等;其中,尤以牙髓炎引起的疼痛最为常见。本文通过查阅近年来国内外牙髓炎疼痛致敏相关文献,从疼痛传导的牙髓神经、三叉神经节、脑干及丘脑腹后内侧核三个传导阶段,就肿瘤坏死因子-α(TNF-α)、白细胞介素-1(IL-1)、促肾上腺皮质激素释放因子受体(CRF)、Toll样受体4(TLR4)、电压门控钠离子通道1.7(Nav1.7)、活化卫星胶质细胞(SGCs)、趋化因子CX3CL1与受体CX3CR1、c-Fos蛋白在牙髓炎疼痛中的作用作出如下综述,并对P2X7受体激活在牙髓炎疼痛中的作用进行了展望,以期为未来开发治疗牙髓炎疼痛的靶向药物提供新的思路。
Pain is an unpleasant defensive response of the body after suffering some harmful stimuli.The common diseases that induce oral and maxillofacial pain in stomatology are pulpitis,trigeminal neuralgia,benign and malignant tumors in maxillofacial region,temporomandibular joint disorder syndrome,and so on.Among them,the pain caused by pulpitis is the most common.In this paper,we reviewed the related literature on pain sensitization of pulpitis at home and abroad in recent years,from the three conduction stages of dental pulp nerve,trigeminal ganglion,brainstem and ventral posterior medial nucleus of thalamus.Besides,the roles of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1),corticotropin-releasing factor receptor(CRF),Toll-like receptor 4(TLR4),sodium channel protein 1.7(Nav1.7),activated satellite glial cell(SGCs),chemokine CX3CL1 and receptor CX3CR1,C-Fos protein in pulpitis pain were reviewed,and the role of P2X7 receptor activation in pulpitis pain was prospected,in order to provide new ideas for the development of targeted drugs for the treatment of pulpitis pain in the future.
作者
徐敏(综述)
肖智
张跃蓉(审校)
XU Min;XIAO Zhi;ZHANG Yue-rong(Zunyi Medical University,Zunyi 563000,Guizhou,CHINA)
出处
《海南医学》
CAS
2021年第6期785-789,共5页
Hainan Medical Journal
基金
贵州省科学技术厅2019年度基础研究计划项目(编号:CK-1165)。
