摘要
肝细胞癌是原发性肝癌的主要病理类型,目前的临床治疗方法难以达到理想的效果,迫切需要探索新的、有效的治疗方法。T细胞受体基因工程改造T细胞(TCR-T)疗法因在实体瘤中的成功应用,被认为是最有前景的免疫治疗方式之一。本文主要从TCR-T治疗在肝细胞癌中的研究进展进行综述,并针对性提出一些解决策略,包括优化TCR亲和力、降低毒性反应、减少外源性和内源性TCR双链错配、改善肿瘤微环境、促进TCR-T细胞扩增。
Hepatocellular carcinoma(HCC)is the main form of liver cancer,and it is difficult to achieve the desirable effect for the current clinical treatment methods.Therefore,it is urgent to explore new and effective treatment methods.T cell receptor-gene engineered T cells(TCR-T)therapy has been proved to be a great promising immunotherapy because of its successful application in solid tumors.In this review,we focus on the occurrence,development and application of TCR-T immunotherapy in HCC.Some strategies are proposed,including optimizing TCR affinity,reducing toxicity,reducing mismatch of double strand in exogenous and endogenous TCR,improving tumor microenvironment,and promoting TCR-T cell expansion.
作者
胡伟
何美芳
Hu Wei;He Meifang(Tumor Center,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China;Surgical Laboratory,the First Affiliated Hospital of Sun Yat-sen University,Guangzhou 510080,China)
出处
《中华普通外科学文献（电子版）》
CAS
2021年第2期152-156,共5页
Chinese Archives of General Surgery(Electronic Edition)
基金
中山大学青年教师培育项目(19ykpy60)。
