摘要
目的评估中药汤剂联合常规西药治疗新型冠状病毒肺炎(COVID-19)的临床疗效和安全性。方法计算机检索中国期刊全文数据库(CNKI)、维普数据库(VIP)、万方数据库及PubMed、Cochran library、Web of science、MEDLINE、Embase等数据库,同时手工检索相关文献的参考文献作为补充,检索时间为2019年12月至2020年9月。由2名研究员独立筛选并提取资料,使用Review Manager 5.4软件进行Meta分析。结果与常规西药治疗组相比,中药汤剂联合常规西药治疗COVID-19在治愈率、总有效率、不良反应、病死率、症状缓解率(发热、气促)、胸部CT改善率方面差异无统计学意义,在咳嗽、疲乏症状缓解率和住院时间方面差异有统计学意义,疗效优于常规西药治疗组。结论中药汤剂联合常规西药治疗COVID-19和在治愈率、总有效率、不良反应、CT改善率以及缓解发热、气促临床症状等方面差异无统计学意义,在缓解咳嗽、疲乏临床症状有一定优势,并能缩短住院时间。
Objective To assess the treatment efficacy and safety of Chinese herbal decoction combined with western medicine on COVID-19 patients.Methods We searched related studies in PubMed,Cochran library,Web of science,MEDLINE,Embase,CNKI,VIP,CBM,Wanfang Data,etc.and manual retrieval of relevant reference was conducted as a supplement.All eligible studies published from December 2019 to September 2020 were included and data were screened and extracted independently by two researchers.Review Manager 5.4 software was used for meta-analysis.Results Meta-analysis showed that compared with the control group(western medicine group),experimental group(Chinese herbal decoction combined with western medicine)witnessed shortened hospital stay,and alleviation of cough and fatigue.There was no significant difference in terms of recovery rate,clinical effective rate,adverse drug events,death rate,CT improvement rate and alleviation of fever and polypnea between the two groups.Conclusion Chinese herbal decoction combined with western medicine has no significant advantages in terms of recovery rate,clinical effective rate,adverse drug events,death rate,CT improvement rate,and alleviation of fever and polypnea,but has certain advantages in shortening hospital stay,and relieving cough and fatigue.However,due to small sample size and uneven quality of the literature,random clinical trials with high-quality large samples are still needed for further verification.
作者
周方方
蒲卢兰
荣欣欣
刘家有
杨懿
刘文娜
ZHOU Fangfang;PU Lulan;RONG Xinxin;LIU Jiayou;YANG Yi;LIU Wenna(Department of Human Anatomy,College of Basic Medicine,North Sichuan Medical College,Nanchong 637100,China)
出处
《实用医学杂志》
CAS
北大核心
2021年第5期564-568,共5页
The Journal of Practical Medicine
基金
2020年四川省科技创新苗子工程培育及小发明小创造项目(编号:2020089)
南充市科技局市校科技战略合作项目(编号:19SXHZ0316)。
