摘要
该文研究多廿烷醇对高脂饮食小鼠和大鼠胆固醇排泄的影响。通过高脂饲料分别喂养小鼠7 d、大鼠10 d和30 d,动物粪便胆固醇排出量显著增加,血脂水平也显著升高。无论是一次灌胃还是连续灌胃,多廿烷醇都能显著地增加高脂动物胆固醇的排泄量,血液中甘油三酯水平也有明显降低。说明多廿烷醇既能抑制胆固醇的吸收,也能促进高血脂大鼠和小鼠对胆固醇的排出,揭示了其对机体胆固醇的代谢有一定的调节作用。
The effect of policosanol on cholesterol excretion in mice and rats with high-fat diet was evaluated in this study.After the high-fat diet on the mice for 7 days,on the rats for 10 days and 30 days respectively,the excretion of cholesterol and blood lipid in animal feces were significantly elevated.It was proved that policosanol could remarkably increase cholesterol excretion and decrease blood triglyceride levels in both single and continuous gavage.These results indicated that policosanol could not only inhibit the absorption of cholesterol,but also promote the excretion of cholesterol in hyperlipidemic rats and hyperlipidemic mice,revealed the metabolic regulation effect of policosanol on cholesterol in the body to some extent.
作者
杨倩
汤静洁
朱艳娇
黄俊生
孟飞
黄冬婷
项辉
YANG Qian;TANG Jing-jie;ZHU Yan-jiao;HUANG Jun-sheng;MENG Fei;HUANG Dong-ting;XIANG Hui(School of Life Sciences,Sun Yat-Sen University,Guangzhou 510006,Guangdong,China;Institute of Bioengineering,Guangdong Academy of Sciences,Guangzhou 510316,Guangdong,China;Guangdong Province Engineering Research Center for Green Technology of Sugar Industry,Guangzhou 510316,Guangdong,China)
出处
《食品研究与开发》
CAS
北大核心
2021年第7期50-55,共6页
Food Research and Development
基金
广州市科技计划项目(201707010357)
广东省科学院发展专项资金项目(2020GDASYL-20200103070)。
关键词
多廿烷醇
胆固醇
胆固醇吸收抑制剂
高脂饮食
降脂作用
policosanol
cholesterol
cholesterol absorption inhibitor
high-fat diet
antilipemic effect
