摘要
目的探讨炎宁糖浆治疗急性上呼吸道感染(外感风热证)的临床疗效及其安全性。方法采用随机、双盲、双模拟、阳性药平行对照、多中心临床试验设计的方法选取北京中医药大学第三附属医院、黑龙江中医药大学附属第二医院、吉林市人民医院、中国人民解放军第二零五医院收治的急性上呼吸道感染(外感风热证)患者69例,采用随机数字表法分为对照组34例和试验组35例。对照组给予口服疏风解毒胶囊,试验组给予口服炎宁糖浆。比较2组主要症状(恶风、发热、咽痛、口渴)改善情况、完全解热时间、单项症状中医证候积分改善有效率及不良反应发生情况。结果试验组主要症状疗效改善情况优于对照组(P<0.05)。2组完全解热时间比较,差异无统计学意义(P>0.05)。治疗后试验组单项症状(恶风、咽痛、口渴、咽部红肿、流涕、咳嗽、全身乏力、头痛、鼻塞)中医证候积分改善有效率高于对照组(P<0.05)。2组均无不良事件及不良反应出现。结论炎宁糖浆治疗急性上呼吸道感染(外感风热证)的临床疗效确切,可改善症状中医证候积分,且安全性较高。
Objective To investigate the clinical efficacy of Yanning syrup in the treatment of acute upper respiratory infections(exogenous wind-heat syndrome).Methods 69 patients with acute upper respiratory tract infection(exogenous wind heat syndrome)were selected from Beijing University of Chinese Medicine Third Affiliated Hospital,the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Jilin People’s Hospital and the 205 Hospital of Chinese People’s Liberation Army by randomized,double-blind,double simulation,positive parallel control and multi center clinical trial design.There were 34 cases in the control group and 35 cases in the experimental group according to random number table.The control group was given Shufengjiedu Capsule,and the experimental group was given Yanning syrup.The improvement of main symptoms(evil wind,fever,sore throat and thirst),the time of complete fever relief,the effective rate of TCM syndrome integral improvement of single symptom and the occurrence of adverse reactions were compared between the two groups.Results The improvement of main symptoms in the experimental group was better than that in the control group(P<0.05).There was no significant difference in the complete antipyretic time between the two groups(P>0.05).After treatment,the effective rate of TCM syndrome integral improvement of the experimental group was higher than that of the control group(P<0.05).There were no adverse events and adverse reactions in both groups.Conclusion Yanning syrup in the treatment of acute upper respiratory tract infection(exogenous wind heat syndrome)has definite clinical effect,can improve symptoms,TCM syndrome score,and with high safety.
作者
崔红生
CUI Hongsheng(Beijing University of Chinese Medicine Third Affiliated Hospital,Beijing 100000,China)
出处
《临床合理用药杂志》
2021年第3期9-11,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
呼吸道感染
炎宁糖浆
外感风热证
临床疗效
Respiratory tract infections
Yanning syrup
Exogenous wind-heat syndrome
Clinical efficacy
