摘要
目的探讨磷酸西格列汀联合二甲双胍对2型糖尿病患者血糖控制及微炎性反应状态的影响。方法选择2017年3月至2019年3月在邢台医学高等专科学校第一附属医院接受治疗的初诊2型糖尿病患者100例,按随机数字表法分为观察组和对照组,每组50例,观察组应用磷酸西格列汀联合二甲双胍治疗,对照组应用二甲双胍治疗,两组均治疗8周。比较两组治疗前后空腹血糖(FBG)、餐后2 h血糖(2 h-PBG)水平变化和达标时间,比较两组治疗前后血清白细胞介素(IL)-1、IL-6、高敏C反应蛋白(hs-CRP)水平。结果治疗后观察组FBG、2 h-PBG水平低于对照组[(6.32±0.83)mmol/L比(7.21±1.03)mmol/L、(8.61±1.26)mmol/L比(9.63±1.12)mmol/L],且观察组FBG、2 h-PBG达标时间短于对照组[(3.11±0.86)周比(4.53±1.31)周、(3.26±0.36)周比(9.63±1.12)周],差异均有统计学意义(P<0.05);治疗后观察组血清IL-1、IL-6、hs-CRP水平低于对照组[(22.86±4.07)ng/L比(35.13±5.92)ng/L、(5.93±0.84)ng/L比(9.67±1.11)ng/L、(2.12±0.25)ng/L比(3.57±0.48)ng/L],差异有统计学意义(P<0.05)。结论磷酸西格列汀联合二甲双胍治疗2型糖尿病可迅速有效控制患者血糖,改善患者微炎性反应状态。
Objective To explore the effects of sitagliptin phosphate combined with metformin on blood glucose control and microinflammation in patients with type 2 diabetes.Methods One hundred patients with newly diagnosed type 2 diabetes who were treated in the First Affiliated Hospital of Xingtai Medical College from March 2017 to March 2019 were randomly divided into observation group(50 cases)and control group(50 cases).The observation group was treated with sitagliptin phosphate combined with metformin for 8 weeks,while the control group was treated with metformin for 8 weeks.The changes of fasting blood-glucose(FBG)and blood glucose 2 h after meal(2 h-PBG)in the two groups before and after treatment were observed,and the standard time of FBG and 2 h-PBG in the two groups were statistically analyzed.The levels of interleukin(IL)-1,IL-6 and high-sensitivity C-reactive protein(hS-CRP)were compared between the two groups before and after treatment.Results After treatment,the levels of FBG and 2 h-PBG in the observation group were significantly lower than those in the control group:(6.32±0.83)mmol/L vs.(7.21±1.03)mmol/L,(8.61±1.26)mmol/L vs.(9.63±1.12)mmol/L,and the standard time of FBG and 2 h-PBG in the observation group were significantly shorter than those in the control group:(3.11±0.86)weeks vs.(4.53±1.31)weeks,(3.26±0.36)weeks vs.(9.63±1.12)weeks,and the differences were statisticlly significant(P<0.05).After treatment,the serum levels of IL-1,IL-6 and hs-CRP in the observation group were significantly lower than those in the control group:(22.86±4.07)ng/L vs.(35.13±5.92)ng/L,(5.93±0.84)ng/L vs.(9.67±1.11)ng/L,(2.12±0.25)ng/L vs.(3.57±0.48)ng/L,and the differences were statistically significants(P<0.05).Conclusions Sitagliptin phosphate combined with metformin in the treatment of type 2 diabetes patients can rapidly and effectively control blood glucose and improve the state of microinflammation in patients.
作者
魏亚兰
吴玉红
胡丽格
孟哲
Wei Yalan;Wu Yuhong;Hu Lige;Meng Zhe(Department of Endocrinology and Nephrology,the First Affiliated Hospital of Xingtai Medical College,Hebei Xingtai 054001,China)
出处
《中国医师进修杂志》
2021年第2期128-132,共5页
Chinese Journal of Postgraduates of Medicine
基金
2019年河北省邢台市科技计划项目(2019ZC266)。
关键词
糖尿病
2型
血糖
磷酸西格列汀
二甲双胍
微炎症
Diabetes mellitus,type 2
Blood glucose
Siglitine phosphate
Metformin
Micro inflammation
