摘要
目的探究妊娠期糖尿病患者肝功能、免疫功能及妊娠结局受乙型肝炎病毒(HBV)感染的影响。方法选取2018年5月至2019年10月鄄城县人民医院收治的45例HBV感染合并妊娠期糖尿病孕妇为观察组,另选取同期收治的45例非HBV感染的妊娠期糖尿病孕妇为对照组。对比两组的氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和总胆红素(TBIL)水平;血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)和白细胞介素-8(IL-8)]、T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+)及CD4^(+)/CD8^(+)比值)和免疫球蛋白[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)]水平;新生儿并发症情况。结果观察组AST、ALT、TBIL水平均高于对照组(P<0.05);观察组TNF-α、IL-6、IL-8高于对照组,CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)低于对照组,CD8^(+)高于对照组,IgA、IgG低于对照组(P<0.05);且观察组早产率、新生儿窒息率、胎儿窘迫率及巨大儿发生率均高于对照组(P<0.05)。结论HBV感染时妊娠期糖尿病患者肝功能、免疫功能及妊娠结局的影响十分明显,HBV感染会对孕妇的肝功能产生影响,降低机体免疫功能,同时还会增加新生儿并发症发生率。因此,临床需要提高对HBV感染的重视度,早期诊断HBV感染合并妊娠期糖尿病孕妇,并对其实施早期干预。
Objective To explore the influence of hepatitis B virus(HBV)infection on liver function,immune function and pregnancy outcome in patients with gestational diabetes.Methods Totally 45 pregnant women with HBV infection combined with gestational diabetes treated in Juancheng County People's Hospital from May 2018 to October 2019 were selected as the observation group,and 45 non-HBV pregnant women with gestational diabetes during the same period were selected as the control group.The levels of AST,ALT and TBIL were compared.Serum levels of inflammatory cytokines[Tumor Necrosis Factor-α(TNF-α),Interleukin-6(IL-6)and Interleukin-8(IL-8)],T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+)and CD4^(+)/CD8^(+)ratios),immunoglobulin[immunoglobulin A(IgA),immunoglobulin G(IgG)]and neonatal complications in the two groups were compared.Results The levels of AST,ALT and TBIL in the observation group were higher than those in the control group(P<0.05);TNF-α,IL-6 and IL-8 in the observation group were higher than those in the control group,and CD3^(+),CD4^(+),CD4^(+)/CD8^(+)were lower than the control group,CD8^(+)was higher than the control group,and IgA and IgG were lower than the control group(P<0.05);and the observation group had higher premature birth rate,neonatal asphyxia rate,fetal distress rate and macrosomia rate(P<0.05).Conclusion The liver function,immune function and pregnancy outcome of gestational diabetes patients are significantly affected by HBV infection,which will affect the liver function of pregnant women,reduce the immune function of the body,and increase the incidence of neonatal complications.Therefore,there is a clinical need to increase the importance of HBV infection,early diagnosis of gestational diabetes women with HBV infection,and early intervention.
作者
张宁
ZHANG Ning(Juancheng County People's Hospital,Heze,Shandong 274600,China)
出处
《大医生》
2020年第23期27-30,共4页
Doctor
关键词
乙型肝炎病毒感染
妊娠期糖尿病
肝功能
免疫功能
妊娠结局
hepatitis B infection
gestational diabetes
liver function
immune function
pregnancy outcome
