摘要
目的初步研究体部立体定向放疗(SBRT)治疗头颈部肿瘤肺寡转移的疗效和安全性。方法回顾性分析2014—2019年间在浙江省肿瘤医院行SBRT治疗头颈部肿瘤肺寡转移患者24例,采用Kaplan-Meier法生存分析。结果24例患者中鼻咽来源12例,非鼻咽来源12例,共34个肺转移病灶行SBRT治疗。中位随访时间19.5个月,SBRT后出现新发病灶者13例,其中9例出现在SBRT治疗1年内。1年实际局控率为95%;中位无进展生存期15.2个月,1、2年无进展生存率分别为59%、46%;肺转移后2、3年总生存率分别为71%、51%。单因素分析显示原发灶位于鼻咽和原发灶治疗后无瘤间期>1年者有生存优势。全组SBRT后均未观察到>3级放射性损伤,轻度放射性损伤发生率为13%。结论SBRT治疗头颈部肿瘤肺寡转移初步显示安全有效,原发肿瘤来源于鼻咽者可能有更好的疗效。
Objective To preliminarily evaluate the efficacy and safety of stereotactic body radiotherapy(SBRT)for pulmonary oligometastatic tumors from head and neck carcinoma.Methods Clinical data of 24 patients with pulmonary oligometastasis from head and neck carcinoma undergoing SBRT in Zhejiang Cancer Hospital from January 2014 to May 2019 were retrospectively analyzed.Survival analysis was performed by Kaplan-Meier method.Results Among the 24 patients,12 cases were diagnosed with nasopharyngeal origin and 12 cases of non-nasopharyngeal origin.A total of 34 pulmonary metastatic lesions were treated with SBRT.The median follow-up time was 19.5 months.Thirteen cases developed new lesions after SBRT,and 9 of them occurred within 1 year after SBRT treatment.The actual 1-year local control rate was 95%.The median progression-free survival was 15.2 months,and the 1-and 2-year progression-free survival were 59%and 46%,respectively.The 2-and 3-years overall survival rate at were 71%and 51%fter lung metastasis,respectively.Univariate analysis showed that the patients with primary lesions located in nasopharynx and disease-free interval of more than 1 year had survival advantage.No more than grade 3 radiation-induced injury was observed in the whole cohort after SBRT,and the incidence of mild radiation-induced injury was 13%.Conclusions SBRT is safe and effective in the treatment of pulmonary oligometastatsis from head and neck carcinoma,and it may be more effective for patients with primary tumors located in nasopharynx.
作者
花永虹
董锐增
朴永锋
王磊
王琼
陶嫦娟
陈媛媛
陈晓钟
胡巧英
陈明
Hua Yonghong;Dong Ruizeng;Piao Yongfeng;Wang Lei;Wang Qiong;Tao Changjuan;Chen Yuanyuan;Chen Xiaozhong;Hu Qiaoying;Chen Ming(Institute of Cancer and Basic Medicine,Department of Radiation Oncology,Chinese Academy of Science,Cancer Hospital of the University of Chinese Academy of Sciences,Zhejiang Cancer Hospital,Hangzhou 310022,China;Department of Cancer and Basic Medicine,Department of Surgery,Chinese Academy of Sciences,Cancer Hospital of the University of Chinese Academy of Sciences,Zhejiang Cancer Hospital,Hangzhou 310022,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2021年第3期235-238,共4页
Chinese Journal of Radiation Oncology
关键词
头颈部肿瘤
肺寡转移/体部立体定向放疗
治疗结果
安全性
Head and neck neoplasm,lung oligometastasis/stereotactic body radiotherapy
Treatment outcome
Safety
