摘要
目的:探讨3D辅助下神经内镜结合吡拉西坦对脑出血患者血清因子和神经功能的影响。方法:选择诊治的78例急性脑出血患者作为研究对象,根据随机数字表法分为联合组(n=39)与对照组(n=39)。对照组给予3D辅助下神经内镜治疗,联合组在对照组治疗的基础上给予吡拉西坦治疗,持续时间为1个月,记录患者血清因子和神经功能变化情况。结果:治疗后联合组的总有效率为97.4%,高于对照组的82.1%(P<0.05)。两组Barthel指数、Fugl-Meyer量表评分对比治疗后高于治疗前,且联合组高于对照组(均P<0.05)。两组治疗后的血清神经元特异性烯醇化酶(NSE)含量低于治疗前(P<0.05),联合组低于对照组(均P<0.05)。治疗期间联合组的再出血、应激性溃疡、颅内感染、肺炎等并发症发生率为5.1%,低于对照组的28.2%(P<0.05)。结论:3D辅助下神经内镜结合吡拉西坦在脑出血的应用能改善患者的神经功能,提高治疗效果,抑制血清NSE的释放,减少并发症的发生。
Objective:To investigate the effect of 3D-assisted neuroendoscopy combined with piracetam on serum factors and neurological function in patients with cerebral hemorrhage.Methods:78 cases of patients with acute cerebral hemorrhage were selected as the research objects.All the cases were divided into the combination group and control group with 39 cases each according to the random number table method.The control group was treated with 3D-assisted neuroendoscopy treatment,and the combination group was treated with piracetam treatment on the basis of the control group for 1 month.The patient’s serum factors and neurological function changes were recorded.Results:After treatment,the total effective rate of the combined group were 97.4%,which were higher than 82.1%of the control group(P<0.05).After treatment,the Barthel index and Fugl-Meyer scale scores of the two groups were higher than those before treatment,and the combination group were also higher than the control group(all P<0.05).The levels of serum neuron-specific enolase(NSE)after treatment in the two groups were lower than those before treatment and the combination group were lower than the control group(all P<0.05).During the treatment,the incidence of rebleeding,stress ulcer,intracranial infection,pneumonia and other complications in the combination group was lower than that in the control group(5.1%vs.28.2%)(P<0.05).Conclusion:The application of 3D-assisted neuroendoscopy combined with piracetam in cerebral hemorrhage can improve the neurological function of patients,improve the therapeutic effect,inhibit the release of serum NSE,and reduce the occurrence of complications.
作者
谢军
刘静静
曾海燕
严忆军
梁珂
XIE Jun;LIU Jingjing;ZENG Haiyan;YAN Yijun;LIANG Ke(Department of Neurosurgery,Tongchuan People’s Hospital,Tongchuan 727000,China)
出处
《陕西医学杂志》
CAS
2021年第4期464-467,共4页
Shaanxi Medical Journal
