摘要
目的探讨妊娠期高脂血症孕妇的高密度脂蛋白(high-density lipoprotein,HDL)抗炎抗氧化功能的变化。方法选取2015年8月至10月在北部战区总医院产科门诊就诊的妊娠期高脂血症孕妇21例作为观察组,按照1∶1的比例选取妊娠期正常孕妇21例作为对照组。应用全自动生化分析仪检测两组孕妇的血脂[血浆总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)];采用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)检测两组孕妇的血清髓过氧化酶(myeloperoxidase,MPO)、C-反应蛋白(C-reactive protein,CRP)、对氧磷酶-1(paraoxonase-1,PON1)、1-磷酸鞘氨醇(sphingosine-1-phosphate,S1P)、血清淀粉样蛋白A(serum amyloid A,SAA)水平。并采用独立样本t检验或Mann-Whitney U检验分析其组间差异。结果观察组PON1[(8±9)μg/L]和S1P[(287±152)nmol/L]低于对照组[分别为(24±62)μg/L、(826±644)nmol/L]。观察组SAA[(4.5±1.8)mg/L]、TC[(5.8±1.0)mmol/L]、TG[(3.0±1.0)mmol/L]、LDL-C[(3.4±0.9)mmol/L]高于对照组[分别为(3.2±1.5)mg/L、(4.8±0.7)mmol/L、(1.7±0.3)mmol/L、(2.5±0.7)mmol/L],差异均有统计学意义(P<0.05);两组CRP、MPO、HDL-C比较差异均无统计学意义(P>0.05)。结论妊娠期高脂血症孕妇HDL的抗炎抗氧化功能下降,SAA、PON1和S1P可以作为临床检测妊娠高脂血症病理学改变的潜在标志物。
Objective To explore changes in the anti-inflammatory and anti-oxidation function of highdensity lipoprotein(HDL)in pregnant women with hyperlipidemia.Methods According to 1∶1 ratio,21 pregnant women with hyperlipidemia(observation group)and 21 healthy pregnant women(control group)were selected from the Department of Obstetrics in General Hospital of Northern Theater Command from August to October 2015.Blood lipids,including total cholesterol(TC),triglyceride(TG),highdensity lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)were tested by automatic biochemical analyzer.Serum myeloperoxidase(MPO),C-reactive protein(CRP),paraoxonase-1(PON1),sphingosine-1-phosphate(S1P)and serum amyloid A(SAA)levels were detected by enzyme linked immunosorbent assay(ELISA).The differences of the above indexes between the two groups were analyzed by independent sample t test or Mann-Whitney U test.Results The serum levels of PON1[(8±9)μg/L]and S1P[(287±152)nmol/L]in observation group were lower than those in the control group[(24±62)μg/L,(826±644)nmol/L respectively],and SAA[(4.5±1.8)mg/L],TC[(5.8±1.0)mmol/L],TG[(3.0±1.1)mmol/L],LDL-C[(3.4±0.9)mmol/L]were higher than those in the control group[(3.2±1.5)mg/L,(4.8±0.7)mmol/L,(1.7±0.3)mmol/L,(2.5±0.7)mmol/L respectively],and all of the differences were statistically significant(P<0.05).The differences of CRP,MPO and HDL-C between the two groups were not significant(P>0.05).Conclusions Hyperlipidemia may be associated with the decline in anti-inflammatory and anti-oxidation function of HDL.SAA,PON1 and S1P may be used as indicators to monitor the changes of the disease.
作者
曲冬颖
陈佳
韩悦
孙静莉
Qu Dongying;Chen Jia;Han Yue;Sun Jingli(Department of Obstetrics and Gynecology,General Hospital of Northern Command,Liaoning,Shenyang 110003,China)
出处
《发育医学电子杂志》
2021年第2期109-113,共5页
Journal of Developmental Medicine (Electronic Version)
基金
2017年中国人民解放军第二〇二医院院课题(2017Y016)。
关键词
妊娠期高脂血症
高密度脂蛋白
抗炎抗氧化功能
总胆固醇
Hyperlipidemia during pregnancy
High-density lipoprotein
Anti-inflammatory and antioxidant function
Total cholesterol
