摘要
目的:观察醒脾祛湿汤治疗湿浊痹阻型胸痹心痛临床效果。方法:82例胸痹心痛患者随机分为两组,对照组给予常规西药治疗,观察组联合醒脾祛湿汤口服治疗。对比两组治疗前后西雅图心绞痛量表评分、血生化指标(hs-CRP、Hcy)、心电图心率变异性(HF、LF),比较两组临床疗效、心电图疗效及不良反应。结果:两组治疗后西雅图心绞痛量表评分,HF、LF、LF/HF指标均明显升高(P<0.05),hs-CRP、Hcy水平均明显降低(P<0.05),且观察组改善均优于对照组(P<0.05);两组治疗后观察组心电图总有效率和临床总有效率均明显高于对照组(P<0.05);两组均未无明显不良反应。结论:醒脾祛湿汤联合西药治疗能够降低胸痹心痛患者血生化指标,改善心电图心率变异性,有助于缓解心痛症状。
Objective:To observe the effect of Xingpi Qushi decoction on the symptoms of heartache,electrocardiogram and the levels of hs-CRP and Hcy in chest pain patients with Shizhuo Bizu type.Methods:82 patients were selected 41 patients in the control group were given sublingual nitroglycerin tablets,oral aspirin enteric coated tablets,oral metoprolol tartrate sustained-release tablets and oral atorvastatin calcium tablets.41 patients in the observation group were given Xingpi Qushi decoction on the basis of the control group for 4 weeks.Before and after treatment,the scores of Seattle angina pectoris scale(physical activity limitation,stable state of angina pectoris,angina pectoris attack,treatment satisfaction and disease awareness),the indexes of blood biochemical[high sensitivity reactive protein(hs-CRP),homocysteine(Hcy)],the ECG heart rate variability[high frequency heart rate(HF),low frequency heart rate(LF)]were compared between the two groups,and the clinical effect,ECG effect and adverse reactions of the two groups were compared.Results:After treatment,the physical activity limitation,stable state of angina pectoris,angina pectoris attack,treatment satisfaction and disease awareness score,the index of HF,LF,LF/HF the two groups were significantly increased(P<0.05),which in the observation group were significantly higher than those in the control group(P<0.05).The serum levels of hs-CRP and Hcy of the two groups were significantly decreased(P<0.05),and the observation group was significantly lower than the control group(P<0.05).After treatment,the total effective rate of ECG in the observation group was 90.2%(37/41),which was significantly higher than 70.7%(29/41)in the control group(χ2=4.970,P<0.05);The total effective rate of the observation group was 92.7%(38/41),which was significantly higher than 73.2%(30/41)in the control group(χ2=5.513,P<0.05).There was no obvious adverse reactions occurred in the two groups during the treatment.Conclusion:The application of Xingpi Qushi decoction combined with western medicine can reduce the serum levels of hs-CRP and Hcy,improve the ECG heart rate variability index,which help to alleviate the symptoms of heartache and improve the clinical treatment effect.
作者
肖进
张新莉
XIAO Jin;ZHANG Xinli(Liangshan Yi Autonomous Prefecture Hospital of Integrated Traditional Chinese and Western Medicine,Xichang 615000,China)
出处
《陕西中医》
CAS
2021年第4期463-466,共4页
Shaanxi Journal of Traditional Chinese Medicine
基金
四川省科技计划项目(2019JDZH0035)。
关键词
胸痹心痛
醒脾祛湿汤
湿浊痹阻型
心绞痛
心电图
心率变异性
Chest pain
Xingpi Qushi decoction
Shizhuo Bizu type
Angina pectoris
Electrocardiogram
Heart rate variability
