摘要
有害真菌已造成植物真菌病害、食物污染和人类真菌感染等问题,给人们的生活和生产带来极大危害,且其逐渐增加对抗真菌药物的耐药性,导致真菌防治日益困难。传统的合成类抗真菌药物具有药物残留和毒副作用,已不能满足需求,作为生物机体天然防御分子的抗真菌肽已成为应对真菌危害及耐药性的重要研究对象。抗真菌肽能够抑制有害真菌,具有高效、广谱、安全的特性,且其独特的抑菌机理解决了真菌耐药性的问题,在真菌防治中逐渐受到关注。基于此,主要从真菌的危害以及抗真菌肽的来源、分离纯化方法、抑菌机理等几个方面进行分析与论述,以期为抗真菌肽的研究提供参考。
The harmful fungi have caused plant fungal disease,food contamination and human fungal infection,which can bring great harm to people’s life and production.Moreover,the increasing resistance of harmful fungi to antifungal drugs has made them difficult to control.Due to the drug residues and the toxic effects,the traditional synthetic fungicides have been unable to meet the people’s needs.Antifungal peptides,as the natural defense molecules of living organisms,have become an important research object in response to fungal hazards and drug resistance.Antifungal peptides can inhibit the harmful fungi,and have the characteristics of high efficiency,broad spectrum and high safety.The unique antifungal mechanism of antifungal peptides can solve the problem of fungal drug resistance,which has gradually attracted people’s attention in fungi control.Based on this,this paper mainly analyzed and discussed the following aspects such as the harm of fungi,the source of antifungal peptides,the method of isolation and purification,the antifungal mechanism of antifungal peptides,etc.,aiming to provide a reference for the study of antifungal peptides.
作者
王志新
鲁雷震
周景波
封成玲
贾紫伟
宁亚维
贾英民
WANG Zhi-xin;LU Lei-zhen;ZHOU Jing-bo;FENG Cheng-ling;JIA Zi-wei;NING Ya-wei;JIA Ying-min(Research Center for Fermentation Engineering of Hebei,College of Bioscience and Bioengineering,Hebei University of Science and Technology,Shijiazhuang 050018;School of Food and Health Engineering,Beijing Technology and Business University,Beijing 100048)
出处
《生物技术通报》
CAS
CSCD
北大核心
2021年第3期206-218,共13页
Biotechnology Bulletin
基金
国家“十三五”重点研发计划项目(2016YFD0400805,2016YFF0202302)
河北省自然科学基金项目(C2020208014)
河北省重点研发计划项目(20327124D)。
关键词
抗真菌肽
真菌危害
分离纯化
抑菌机理
antifungal peptides
fungal hazard
isolation and purification
antifungal mechanism
