摘要
肠道菌群是人体重要的微生态系统,在机体的生理病理过程中发挥重要作用。肠道菌群有助于保证机体生命活动的正常进行,菌群失调则会诱发多种疾病。近年来,针灸通过调节肠道菌群发挥治疗作用的研究逐渐成为热点,研究表明,针灸可以通过调节肠道菌群对不同系统的疾病发挥治疗作用,如消化系统、内分泌系统、循环系统、神经系统、免疫系统,其作用机制可能与调控Toll样受体(TLR)/髓样分化因子88(MyD88)/核转录因子-κB(NF-κB)信号通路、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(AKT)信号通路、菌群-肠-脑轴的下行通路有关。
Intestinal flora is an important microecosystem of human body, which plays an important role in physiological and pathological process. Intestinal flora is helpful to ensure the normal life activities of the body, and dysbacteriosis can induce a variety of diseases. In recent years, acupuncture and moxibustion play a therapeutic role by regulating the intestinal flora, which has gradually become the hot spot of research. Studies have shown that acupuncture and moxibustion can play the therapeutic role in diseases of different systems by regulating the intestinal flora, such as digestive system, endocrine system, circulation system, nervous system and immune system, and its mechanism may be related to the regulation of Toll-like receptor(TLR)/myeloid differentiation factor 88(MyD88)/nuclear factor-κB(NF-κB) signaling pathway, phosphatidylinositol 3-kinase(PI3 K)/protein kinase B(AKT) signaling pathway, and descending pathway of bacteria-gut-brain axis.
作者
吴小丽
黄光瑞
李晓璐
霍瑰阳
蒋海旭
冯玉音
刘鑫
刘清国
贾文睿
WU Xiaoli;HUANG Guangrui;LI Xiaolu;HUO Guiyang;JIANG Haixu;FENG Yuyin;LIU Xin;LIU Qingguo;JIA Wenrui(School of Acupuncture-moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 102488,China;School of Life Sciences,Beijing University of Chinese Medicine,Beijing 102488,China)
出处
《上海中医药大学学报》
CAS
2021年第2期103-108,共6页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家自然科学基金重点项目(81430099)
国家国际科技合作专项项目(2014DFA32950)。
关键词
针灸
肠道菌群
机制
综述
acupuncture-moxibustion
intestinal flora
mechanism
review
