摘要
目的探讨非肌层浸润性膀胱癌(NMIBC)患者经尿道膀胱肿瘤电切术(TURBT)治疗预后复发与术前白蛋白/球蛋白(A/G)比值的关系。方法选取2012年9月~2014年9月我院收治的经TURBT治疗的NMIBC患者152例。对入选患者的资料进行整理归纳,统计其检查结果(A/G比值,根据术前A/G正常参考值,将A/G值<1.5归为低A/G,将A/G≧1.5归为高A/G)、临床病理特征(年龄、性别、肿瘤分期、分级、数量、大小等)以及随访5年预后(复发)情况。根据随访结果统计所有患者术后复发情况,并根据其有无复发分为复发组和未复发组,采用多元Logistic分析影响NMIBC患者预后复发的相关因素。结果经统计结果显示:152例NMIBC经TURBT治疗患者随访率为100.00%,术后复发率为21.05%(32/152),余120例未见复发;单因素分析发现年龄越大、肿瘤分期与分级越高、肿瘤数量越多、术前低A/G及肿瘤直径越大NMIBC患者经TURBT术后复发率越高(P<0.05);经多元Logistic回归分析肿瘤分期、肿瘤分级、肿瘤数量、术前A/G与肿瘤直径均为NMIBC患者预后复发的独立预测指标(P<0.05)。结论A/G比值是影响NMIBC患者经TURBT治疗后复发的独立影响因素,在根据患者临床病理特征及肿瘤特性对其预后进行评估的同时,予以术前A/G比值进行辅助检测更有利于预测患者术后复发风险,在临床医生对患者的危险程度进行评估并制定针对性治疗方案上具有更好的临床意义。
Objective:To explore the relationship between prognostic recurrence and the preoperative albumin/globulin(A/G)ratio in patients with non-muscular invasive bladder cancer(NMIBC)after transurethral resection of bladder tumor(TURBT).Methods:152 NMIBC patients treated with TURBT in this hospital from September 2012 to September 2014 were selected.The data of selected patients were sorted and summarized,and the results of examination(A/G ratio,according to the normal reference value of A/G before surgery,A/G value<1.5 is classified as low A/G,and A/G≧1.5 is classified as high A/G),clinicopathological characteristics(age,gender,tumor stage,grade,number,size,etc.)and prognosis(recurrence)in follow-up within 5 years are counted.According to the results of the follow-up,the postoperative recurrence of all patients was counted and all patients were divided into recurrence group and non-recurrence group according to whether they had recurrence or not.Multivariate Logistic analysis was used to analyze the related factors affecting the prognostic recurrence of patients with nonmuscular invasive bladder cancer.Results:The statistical results showed that the follow-up rate of 152 NMIBC patients treated with TURBT was 100.00%,the postoperative recurrence rate was 21.05%(32/152),and the remaining 120 cases had no recurrence.Univariate analysis found that the older the age was,the higher the tumor stage and grade were,the greater the number of tumors was,the larger the preoperative low A/G and the tumor diameter were,and the higher the recurrence rate of NMIBC patients after TURBT was(P<0.05).Multivariate logistic regression analysis showed that tumor stage,tumor grade,tumor number,preoperative A/G and tumor diameter were all independent predictors of prognostic recurrence in NMIBC patients(P<0.05).Conclusion:The A/G ratio is an independent factor that affects the recurrence of NMIBC patients after TURBT treatment.While the prognosis of the patient is evaluated based on the clinicopathological characteristics and tumor characteristics,the auxiliary test of the preoperative A/G ratio is more conducive to predicting the risk of postoperative recurrence of the patient,which has better clinical significance for clinicians to assess the risk of patients and formulate targeted treatment plans.
作者
马强
江永浩
车兴奎
雷星辉
Qiang Ma;Yonghao Jiang;Xingkui Che;Xinghui Lei(Department of Urology,the second people’s Hospital of Yibin City,Yibin,Sichuan 644000)
出处
《西藏医药》
2021年第2期17-19,共3页
Tibetan Medicine
关键词
术前白蛋白/球蛋白
非肌层浸润性膀胱癌
经尿道膀胱肿瘤电切术
复发
影响因素
Preoperative albumin/globulin
Non-muscular invasive bladder cancer
Transurethral resection of bladder tumor
Recurrence
Influencing factors
