摘要
目的系统评价柴芍六君子汤联合经肝动脉栓塞化疗(TACE)治疗原发性肝癌的效果。方法计算机检索中英文文献数据库,检索柴芍六君子汤加减联合TACE(试验组)与TACE(对照组)治疗中晚期原发性肝癌患者的随机对照研究(RCTs),检索时限均为从建库至2019年11月30日,采用RevMan 5.3软件进行Meta分析。结果Meta分析结果显示,试验组的卡氏功能状态评分(KPS)高于对照组(MD=9.43,95%CI=6.59~12.27,P<0.00001)、胆红素上升低于对照组(RR=0.48,95%CI=0.31~0.74,P=0.001)、恶心呕吐低于对照组(RR=0.54,95%CI=0.31~0.94,P=0.03)、腹痛低于对照组(RR=0.56,95%CI=0.40~0.79,P=0.001)、发热低于对照组(RR=0.60,95%CI=0.42~0.85,P=0.005),差异均有统计学意义。两组的实体瘤控制(RR=1.04,95%CI=0.93~1.17,P=0.48)、白细胞降低(RR=0.76,95%CI=0.48~1.20,P=0.24)、血小板降低(RR=0.81,95%CI=0.52~1.24,P=0.32)比较,差异均无统计学意义。结论柴芍六君子汤联合TACE可以明显提高KPS评分,减少化疗不良反应的发生。
Objective To systematically evaluate the efficacy of Chaishao Liujunzi Decoction combined with transarterial chemoembolization(TACE)in the treatment of primary liver cancer.Methods The Chinese and English literature databases were searched by computer,and randomized controlled studies(RCTs)of Chaishao Liujunzi Decoction combined with TACE(experimental group)and TACE(control group)on patients with advanced primary liver cancer were searched.The retrieval time was from the time of building the repository to November 30,2019.RevMan 5.3 software was used for Meta-analysis.Results The Meta-analysis showed that the Karnofsky performance status(KPS)score of the experimental group was higher than that of the control group(MD=9.43,95%CI=6.59-12.27,P<0.00001),the increase of bilirubin was lower than that of the control group(RR=0.48,95%CI=0.31-0.74,P=0.001),the nausea and vomiting was lower than that of the control group(RR=0.54,95%CI=0.31-0.94,P=0.03),the abdominal pain was lower than that of the control group(RR=0.56,95%CI=0.40-0.79,P=0.001),and the fever was lower than that of the control group(RR=0.60,95%CI=0.42-0.85,P=0.005),and the differences were statistically significant.There were no significant differences in solid tumor control(RR=1.04,95%CI=0.93-1.17,P=0.48),leukopenia(RR=0.76,95%CI=0.48-1.20,P=0.24)and thrombocytopenia(RR=0.81,95%CI=0.52-1.24,P=0.32)between the two groups.Conclusion Chaishao Liujunzi Decoction combined with TACE can significantly improve KPS score and reduce the occurrence of adverse reactions to chemotherapy.
作者
邱汉波
赵艺蔓
周尧红
郑景辉
彭启龙
侯恩存
QIU Han-bo;ZHAO Yi-man;ZHOU Yao-hong;ZHENG Jing-hui;PENG Qi-long;HOU En-cun(Department of Oncology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530011,China;Department of Cardiology,Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Guangxi Zhuang Autonomous Region,Nanning530011,China)
出处
《中国当代医药》
CAS
2021年第10期20-22,27,共4页
China Modern Medicine
关键词
柴芍六君子汤
肝癌
经肝动脉栓塞化疗
META分析
Chaishao Liujunzi Decoction
Liver cancer
Transarterial chemoembolization
Meta-analysis
