摘要
目的探讨齐拉西酮联合奥氮平治疗难治性精神分裂症(TRS)的效果及安全性。方法选取2018年3月~2019年12月于枣庄市精神卫生中心和菏泽市第三人民医院确诊的72例TRS患者作为研究对象,根据随机数字表法将患者分为对照组(奥氮平治疗)、观察组(对照组基础上给予齐拉西酮治疗),每组各36例。于治疗前及治疗3个月后采用阳性与阴性症状量表(PANSS)评估患者症状严重程度,根据PANSS评分结果,计算总有效率;采用韦氏记忆量表(WMS)和连线测试(TMT)评估患者认知功能;比较两组的不良反应总发生率。结果观察组患者的治疗总有效率(91.67%)高于对照组(72.22%),差异有统计学意义(P<0.05)。两组患者治疗后的WMS评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组患者治疗后的TMT评分均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。对照组流涎、头晕头痛、嗜睡、便秘、癫痫的不良反应总发生率为27.78%,观察组为19.44%,两组比较,差异无统计学意义(P>0.05)。结论齐拉西酮联合奥氮平治疗TRS的效果较好,可显著改善患者的认知功能,且不会增加不良反应总发生率。
Objective To investigate the effect and safety of Ziprasidone combined with Olanzapine in the treatment of treatment-resistant(TRS).Methods A total of 72 TRS patients diagnosed at Zaozhuang Mental Health Center and Heze Third People′s Hospital from March 2018 to December 2019 were selected as the research objects.According to the random number table method,the patients were divided into the control group(Olanzapine treatment)and the observation group(Ziprasidone treatment based on the control group),with 36 cases in each group.Before treatment and after 3 months of treatment,the positive and negative symptom scale(PANSS)was performed to assess the severity of symptoms in patients,and the total effective rate was calculated based on the PANSS score.The Wechsler memory scale(WMS)and trail making test(TMT)were used to evaluate the patients′cognitive function.The total incidence of adverse reactions was compared between the two groups.Results The total effective rate of treatment in the observation group(91.67%)was higher than that in the control group(72.22%),with statistically significant difference(P<0.05).After treatment,the WMS scores of the two groups were higher than those before treatment,and the WMS score in the observation group was higher than that in the control group,with statistically significant differences(P<0.05).The TMT scores of the two groups were lower than those before treatment,and the TMT score in the observation group was lower than that in the control group,with statistically significant differences(P<0.05).The total incidence of adverse reactions such as salivation,dizziness,headache,drowsiness,constipation and epilepsy in the control group was 27.78%,and 19.44%in the observation group,there was no significant difference between the two groups(P>0.05).Conclusion The combination of Ziprasidone and Olanzapine has a good effect in the treatment of TRS,which significantly improves the cognitive function of patients without increasing the total incidence of adverse reactions.
作者
曹保瑞
陈家民
马庆
CAO Bao-rui;CHEN Jia-min;MA Qing(Zaozhuang Mental Health Center,Shandong Province,Zaozhuang277000,China;Heze Third People′s Hospital,Shandong Province,Heze274000,China)
出处
《中国当代医药》
CAS
2021年第10期113-116,共4页
China Modern Medicine
关键词
难治性精神分裂症
齐拉西酮
奥氮平
Treatment-resistant schizophrenia
Ziprasidone
Olanzapine
