摘要
白桦脂酸是一种具有多种药理活性的五环三萜类天然产物,已报道的其单晶体均为白桦脂酸-有机溶剂形式。本研究通过溶剂挥发法制备了白桦脂酸-乙醇(1:1)单晶体,通过X射线衍射法获得了其单晶数据,用Hirshfeld surface分析法对晶体中分子间作用力进行了分析。晶体结构分析结果为揭示其理化性质与成因等提供了基础科学数据,为该晶型的定性、定量分析及制备工艺研究提了标准依据,为白桦脂酸多晶型的筛选及共晶的设计提供了数据参考。
Betulinic acid is a naturally occurring pentacyclic triterpenoid with various pharmacological activities.All of the reported single crystals of betulinic acid are in the form of betulinic acid-organic solvents.Betulinic acid-ethanol(1:1)single crystal was prepared by evaporation method,its single crystal data was obtained by X-ray diffraction,and the molecular interaction in the crystal were analyzed by Hirshfeld surface analysis.The results of crystal structure analysis provided basic scientific data for revealing the physichemical properties and the mechanism of formation of the crystal,standard basis for the qualitative,quantitative and preparation study of this crystal form,data reference for the screening of polymorphs and the design of cocrystals of Betulinic acid.
作者
刘颖
高松琳
彭亭涛
崔彩霞
褚光松
LIU Ying;GAO Song-lin;PENG Ting-tao;CUI Cai-xia;CHU Guang-song(Shandong First Medical University&Shandong Academy of Medical Sciences,Shandong Tai'an 271016,China)
出处
《广州化工》
CAS
2021年第7期52-55,共4页
GuangZhou Chemical Industry
基金
国家级大学生创新训练项目(201810439024)。
