摘要
Kisspeptin是调节女性生殖功能重要的神经肽,主要在下丘脑促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)神经元的上游起作用,与GnRH神经元上的相应受体GPR54结合后刺激GnRH的释放,从而导致生殖轴后续一系列的活动。然而,近年来研究显示,Kisspeptin不仅在中枢下丘脑和垂体调控女性生殖功能,而且在卵巢局部也发挥作用。卵巢局部的Kisspeptin不仅参与调控卵母细胞、颗粒细胞、黄体的功能,同时又受促性腺激素、光周期、交感神经、代谢的影响。本文就Kisspeptin的中枢调控以及卵巢局部作用进行综述。
Kisspeptin is an important neuropeptide regulating female reproductive function.It mainly acts on the upstream of hypothalamic gonadotropin-releasing hormone(GnRH)neurons.It binds to the corresponding receptor GPR54 on GnRH neurons to stimulate the release of GnRH,which leads to a series of subsequent activities of the reproductive axis.However,in recent years,it has been found that Kisspeptin exists not only in the central hypothalamus and pituitary,but also in the peripheral ovary,indicating that Kisspeptin not only regulates the female reproductive function in the central,but also plays a local role in the ovary.Kisspeptin is not only involved in the regulation of oocyte,granulosa cell and luteal function,but also affected by gonadotropin,photoperiod,sympathetic nerve and metabolism.This article reviews the central regulation effect and the local ovarian role of of kisspeptin.
作者
杨立
王青
王志
董浩旭
程玲
黄冬梅
Yang Li;Wang Qing;Wang Zhi;Dong Haoxu;Cheng Ling;Huang Dongmei(Institute of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Rehabilitation Center of Wuhan Puren Hospital,Affiliated Hospital of Wuhan University of Science and Technology,Wuhan 430081,China;Department of Integrated Traditional Chinese and Western Medicine,Tongji Hospital,Huazhong University of Science and Technology,Wuhan 430030,China;Department of Acupuncture and Moxibustion,East Hospital,Shanghai 200120,China)
出处
《中华生殖与避孕杂志》
CSCD
北大核心
2021年第2期177-183,共7页
Chinese Journal of Reproduction and Contraception
基金
国家自然科学基金(81573787)
上海市浦东新区卫生系统重点学科群建设资助(PWZxq2017-13)。
