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体外受精-胚胎移植中男方少弱精子症与胚胎质量及妊娠结局的相关研究 被引量:12

Studies on the relationship among male oligospermia or asthenozoospermia with embryo quality and pregnancy outcome of in vitro fertilization-embryo transfer
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摘要 目的探讨体外受精-胚胎移植中男方少弱精子症和正常质量精子与胚胎质量及妊娠结局的关系。方法回顾性分析2016年5月至2019年8月昆明医科大学第一附属医院生殖中心行IVF助孕的693对不孕症夫妇共693个取卵周期和2893枚胚胎的临床资料及实验室数据,根据男方的精子质量,分为正常组(n=607)和少弱精子症组(n=86),对比两组的男方年龄、女方年龄、精液基础资料(包括禁欲天数、液化时间、精液量、精子密度、前向运动精子)、正常受精率、优质胚胎率、囊胚形成率、胚胎着床率和临床妊娠率。结果两组男方、女方平均年龄无统计学差异(P>0.05);除囊胚培养率外,两组的正常受精率、优质胚胎率、胚胎着床率和临床妊娠率均无统计学差异(P>0.05)。结论在IVF助孕的夫妇中,男方少弱精子症不影响优质胚胎率、胚胎着床率和临床妊娠率。 Objective To explore the relationship among oligospermia or asthenozoospermia and normozoospermia in males with embryo quality and pregnancy outcomes.Methods Clinical data of this retrospective study included 693 infertile couples,who received 693 cycles of in vitro fertilization-embryo transfer(IVF-ET)treatment since May 2016 to Aug 2019,were retrospectively analyzed.Cycles were grouped into the normal group(n=607)and the unnormal group(n=86).This study has compared clinical and laboratorial outcomes between these two groups were comparatively analyzed.Results The mean paternal ages in the normal and unnormal groups were 36.17 and 36.55 years,respectively(P>0.05).The days of abstinence,liquefaction times of semen,semen volume were similar between the two groups(P>0.05).There was a significant difference in blastocyst formation rates(51.77 vs.58.56,P=0.02)between the two groups.But the rates of normal fertility(70.19 vs.68.27,P=0.27),good-quality embryo(79.96 vs.79.61,P=0.88),imnplantation(24.10 vs.28.95,P=0.51)and clinical pregnancy(35.02 vs.30.43,P=0.66)were similar between the two groups.Conclusion Our data suggested that there was no significant differences between normal and unnormal groups in terms of rates of good-quality embryo,implantation and clinical pregnancy.
作者 苏梦驰 王华伟 饶猛 龙艳喜 徐玉庭 唐莉 Su Mengchi;Wang Huawei;Rao Meng;Long Yanxi;Xu Yuting;Tang Li(The First Affiliated Hospital of Kunming Medical University,Kunming Yunnan,650000)
出处 《中国男科学杂志》 CAS CSCD 2021年第1期7-10,共4页 Chinese Journal of Andrology
基金 AMH在云南不同民族育龄期女性外周血中的差异表达及其遗传机制研究(2018FE001(-202)) 线粒体DNA损伤致男性精子质量下降机制研究(ZDFY2019-RG-0005)。
关键词 体外受精-胚胎移植(IVF) 少精子症 弱精子症 胚胎质量 妊娠结局 in vitro fertilization-embryotransfer(IVF) Oligospermia Asthenozoospermia Embryo quality Pregnancy outcome
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