摘要
目的我国的许多民族医药和组合药物在长期的临床实践中具有显著的疗效,但其活性成分及作用机制尚不清楚,我们探究了系统药理学方法在民族医药和组合药物的应用现状,以期为相关研究者提供参考。方法将系统药理学方法在藏医药、蒙医药、维吾尔医药等民族医药和组合药物两个领域的研究成果进行汇总、论述和分析。结果在民族医药的研究中,研究者们采用系统药理学方法科学的阐明了"血液质论"、"同病异治"等中医基础理论。在组合药物的研究中,我们发现系统药理学方法在解释中草药组合的合理性、减轻药物诱导的不良反应、解决不同患者之间的反应变异性等方面有着重大意义。结论系统药理学研究体系有助于阐释药物的药效物质基础、作用机制和中医基础理论,为民族医药的现代化发展、组合药物的研究提供了新方法学。
Objective:Many ethnic medicines and combination drugs in China have significant effects in long-term clinical practice,but the active ingredients and mechanism of action are still unclear. This paper aims to explore the application status of systemic pharmacology methods in ethnic medicines and combination drugs,with a view to provide reference for relevant researchers. Methods:The systematic pharmacology methods were summarized,discussed and analyzed in the fields of Tibetan medicine,Mongolian medicine,Uyghur medicine and other national medicines and combination medicines. Results:In the study of ethnic medicine,the researchers used systematic pharmacology to scientifically clarify the basic theories of traditional Chinese medicine such as "blood quality theory" and "same disease treatment." In the study of combination drugs,we found that systemic pharmacology has great significance in explaining the rationality of Chinese herbal medicine combination,reducing drug-induced adverse reactions,and solving the reaction variability between different patients.Conclusion:The systemic pharmacology research system is helpful to explain the pharmacodynamic basis,mechanism of action and basic theory of Chinese medicine,and provides a new methodology for the modernization of ethnic medicine and the research of combination drugs.
作者
张鲁霞
石彬彬
李丰
李燕
ZHANG Luxia;SHI Binbin;LI Feng;LI Yan(School of Chemical Engineering,Dalian University of Technology,Dalian 116024,China;ZhengzhouYuancaozhen Research Institute of Traditional Chinese Medicine,Zhengzhou 450000,China)
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2021年第2期217-225,共9页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金重点项目(81530100)。
关键词
系统药理学
民族医药
组合药物
systems pharmacology
national medicine
combined drugs
