摘要
扩张型心肌病(dilated cardiomyopathy,DCM)是以扩大的心室和收缩功能障碍为特征的一种心肌病。DCM在所有心肌病中发病率最高,是一种严重威胁人类健康与生命的重大慢性病。DCM的病因及发病机制未完全明确,亦无特效药物及方法。因此,探寻DCM新的发病机制,从而寻找新的治疗方法和药物靶点,对临床救治具有重大意义。表观遗传学是不改变基因序列而引起的细胞表型和基因表达的可遗传改变,并受基因与环境相互作用的影响。本文将从DNA甲基化、组蛋白修饰、染色质重塑和非编码RNA等4个主要表观遗传学角度,综述DCM表观遗传学领域的一些新进展,为诊治DCM提供潜在的新途径。
Dilated cardiomyopathy(DCM) has the highest morbidity among all the cardiomyopathies which was characterized by enlarged ventricle and loss of systolic function. DCM is a serious chronic disease which seriously threatens human health. The etiology and pathogenesis of DCM are not completely clear, and there is no specific treatment drugs and methods. Therefore, it is great important for clinical treatment to explore the new pathogenesis of DCM and find new treatment methods and drug targets. Epigenetics does not involve the changes of genetic sequences but focuses on the stable inheritance of genes in different individuals. It is affected by the interaction between genes and environments. We present some of the recent progress in the field of epigenetics in DCM by focusing on the three major epigenetic modifications, that is, DNA methylation, histone modification, chromatin remodeling, and noncoding RNAs which have the promise to yield potential new avenues for more effective treatment of the disease.
作者
沈丽娟
陆曙
孔令晶
杨葛魏
邢清敏
SHEN Lijuan;LU Shu;KONG Lingjing;YANG Gewei;XING Qingmin(Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine,Wuxi,Jiangsu,214071,China;Nanjing University of Chinese Medicine)
出处
《临床心血管病杂志》
CAS
北大核心
2021年第2期100-104,共5页
Journal of Clinical Cardiology
基金
江苏省自然科学基金面上项目(No:BK20201141)
江苏省中医药管理局领军人才培养(No:SLJ0217)
无锡市2019年度“太湖人才计划”国际国内顶尖医学团队(No:锡组通【2019】68号)
无锡市“双百”中青年医疗卫生拔尖人才(No:BJ2020067)。
关键词
扩张型心肌病
表观遗传学
DNA甲基化
组蛋白
非编码RNA
dilated cardiomyopathy
epigenetics
chromatin
DNA methylation
histone modification
noncoding RNAs
