摘要
目的探讨分析脂蛋白相关磷脂酶A2(Lp-PLA_(2))在急性脑梗死患者中的表达及其与颈动脉粥样硬化斑块的关系。方法选取扬州洪泉医院2019年9月至2020年8月收治的70例急性脑梗死患者为研究组,同时选取同期于该院体检的50例非脑梗死患者作为对照组。比较组间、组内血清学检查结果差异。结果研究组脑梗死患者血清脂蛋白相关磷脂酶A_(2)(Lp-PLA_(2))、超敏C反应蛋白(hs-CRP)、总胆固醇(TC)等各项指标表达均与对照组非脑梗死体检者表达存在显著性差异,(P<0.05);研究组组内对比后发现,轻度动脉粥样硬化者Lp-PLA_(2)、hs-CRP、TC等指标较中度、重度动脉粥样硬化板块者存在显著性差异(P<0.05)。急性脑梗死患者血清Lp-PLA_(2)水平分类对比后:以颈动脉内-中膜厚度(IMT)指标分组:斑块形成者>内膜增厚者>内膜正常者,以斑块积分分组:重度动脉粥样硬化者>中度动脉粥样硬化者>轻度动脉粥样硬化者,以颈动脉狭窄程度分组:重度狭窄者>中度狭窄者>轻度狭窄者,比较差异均具有统计学意义(P<0.05)。结论Lp-PLA_(2)与动脉粥样硬化性脑梗死的发生以及动脉粥样硬化严重程度有着密切联系,监测血清Lp-PLA_(2)水平可以作为评估急性脑梗死患者病情严重程度的生物学指标之一。
Objective To investigate the expression of Lp-PLA_(2) in patients with acute cerebral infarction and its relationship with carotid atherosclerotic plaque.Methods Totally 70 patients with acute cerebral infarction admitted to Yangzhou Hongquan Hospital from September 2019 to August 2020 were selected as study group,and 50 non-cerebral infarction patients who underwent physical examination in the hospital during the same period were selected as the control group.The results of serology in study group and between two groups were compared.Results The expressions of serum Lp-PLA_(2),hs-CRP and TC in the cerebral infarction patients of the study group were significantly different from those in the non-cerebral infarction patients in the control group,(P<0.05).After comparison within the study group,it was found that Lp-PLA_(2),hs-CRP,TC and other indicators of mild atherosclerosis were significantly different than those with moderate and severe atherosclerosis(P<0.05).After classification and comparison of serum Lp-PLA_(2) levels in patients with acute cerebral infarction:group by IMT index:plaque formation>intimal thickening>normal intima,grouped by plate score:severe atherosclerosis>moderate atherosclerosis>mild atherosclerosgrouped by the degree of carotid artery stenosis:severe stenosis>moderate stenosis>mild stenosis,and the differences were statistically significant(P<0.05).Conclusion Lp-PLA_(2) is closely related to the occurrence of atherosclerotic cerebral infarction and the severity of atherosclerosis.Monitoring serum Lp-PLA_(2) level can be used as one of the biological indicators to assess the severity of acute cerebral infarction patients.
作者
苏秀瑾
SU Xiujin(Yangzhou Hongquan Hospital,Yangzhou.Jiangsu 225200,China)
出处
《大医生》
2020年第24期123-125,共3页
Doctor
