摘要
目的:探究薏苡附子败酱方对痛风性关节炎(湿热痹阻证)患者疗效、关节功能、血清促炎因子影响。方法:符合纳入标准的134例痛风性关节炎(湿热痹阻证)患者采用随机数字表分为对照组和观察组。对照组(67例)采用西医常规治疗,观察组(67例)在对照组基础上采用薏苡附子败酱方治疗,比较两组患者临床疗效、治疗前后中医症状(关节红肿热痛、发热烦闷、活动不利、口渴便黄)积分变化、关节恢复评分变化、血沉及血尿酸水平变化、血清促炎因子水平变化和不良反应情况。结果:观察组患者治疗总有效率(97.01%,65/67)高于对照组(88.06%,59/67)(P<0.05);治疗前,两组患者关节红肿热痛、发热烦闷、活动不利、口渴便黄的中医症状积分,关节疼痛及关节压痛、关节功能等关节恢复评分,血沉及血尿酸水平、C-反应蛋白(CRP)、白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)等血清促炎因子水平比较,没有统计学意义(P>0.05);治疗后各组患者关节红肿热痛、发热烦闷、活动不利、口渴便黄的中医症状积分,关节疼痛及关节压痛、关节功能等关节恢复评分,血沉及血尿酸水平、CRP、IL-1β、TNF-α等指标均改善(P<0.05),观察组患者治疗后关节红肿热痛、发热烦闷、活动不利、口渴便黄的中医症状积分,关节疼痛及关节压痛、关节功能等关节恢复评分,血沉及血尿酸水平、CRP、IL-1β、TNF-α等指标均优于对照组(P<0.05);观察组治疗过程中未见不良反应,对照组出现1例胃肠道反应(1.49%)(P>0.05)。结论:薏苡附子败酱方治疗痛风性关节炎(湿热痹阻证)效果显著,患者关节恢复良好,疼痛缓解,炎症因子水平下降,无不良反应,安全性高。
Objective:To explore the effect of Yiyi Fuzi Baijiang Formula on curative efficacy,joint function and serum proinflammatory factors in patients with gout arthritis(impediment of dampness-heat).Methods:134 patients with gouty arthritis(impediment of dampness-heat)were randomly divided into the control group(n=67)and the observation group(n=67).The control group was treated with conventional western medication;on which basis,the observation group was also treated with Yiyi Fuzi Baijiang Formula.Clinical efficacy,the scores of TCM symptoms(heat joint,swelling pain,hot feeling and chest distress,restricted movement,thirst and yellowish urine),the scores of joint recovery,the levels of blood sedimentation,blood uric acid and proinflammatory factors,as well as adverse reactions were compared between the two groups before and after the treatment.Results:The total effective rate was 97.01%(65/67)in the observation group,which was significantly higher than 88.06%(59/67)in the control group(P<0.05).There were no statistical differences in the scores of TCM symptoms and joint recovery,as well as in the levels of blood sedimentation,blood uric acid,CRP,IL-1βand TNF-αbetween the two groups before the treatment(P>0.05);which were all improved after the treatment compared to those before the treatment in the two groups(P<0.05);the improvements in the observation group were more significant(P<0.05).No adverse reactions were observed during the treatment in the observation group,and one incidence of gastrointestinal reactions was seen in the control group,but there was no statistical difference in adverse reactions between the two groups(P>0.05).Conclusion:Yiyi Fuzi Baijiang Formula is effective in treating gout arthritis(impediment of dampness-heat),which can better improve joint recovery,relieve pain and reduce inflammatory factors,with its high safety.
作者
陶江涛
张敏
刘方
马玉
TAO Jiangtao;ZHANG Min;LIU Fang;MA Yu(Nanshi Hospital of Nanyang, Nanyang 473000, China)
出处
《中医药信息》
2021年第4期72-76,共5页
Information on Traditional Chinese Medicine
关键词
痛风性关节炎
湿热痹阻证
急性期
薏苡附子败酱方
疗效
关节功能
Gout arthritis
Syndrome of dampness-heat impediment
Acute phase
Yiyi Fuzi Baijiang Formula
Curative effect
Joint function
