摘要
目的观察针刺联合盐酸羟考酮缓释片治疗椎体转移所致重度癌性疼痛患者的临床疗效及对患者疼痛程度的影响。方法将纳入的108例椎体转移所致重度癌性疼痛患者按照随机数字表法分为研究组和对照组,每组54例。对照组采用口服盐酸羟考酮缓释片治疗,研究组在对照组治疗基础上联合针刺治疗。比较两组疼痛缓解情况;采用抑郁自评量表(SDS)和焦虑自评量表(SAS)评估患者抑郁和焦虑情况;用生活质量量表(QOL)评价两组患者治疗前后生活质量。观察两组消化系统毒副反应发生情况。结果研究组疼痛总缓解率明显高于对照组,两组差异具有统计学意义(P<0.05)。治疗后,两组SAS、SDS和NRS评分均较治疗前降低(P<0.05),且研究组均低于对照组(P<0.05);研究组生活质量良好率和QOL总分均明显高于对照组,两组比较差异具有统计学意义(P<0.05)。两组消化系统不良反应发生率比较,差异无统计学意义(P>0.05)。结论针刺联合盐酸羟考酮缓释片治疗椎体转移所致重度癌性疼痛患者可有效缓解疼痛,改善抑郁和焦虑状态,提升生活质量。
Objective To observe the clinical efficacy of acupuncture plus Oxycodone Hydrochloride sustained release tablets for severe cancer pain caused by vertebral metastasis and its effect on pain severity in the patients.Method One hundred and eight patients with severe cancer pain caused by vertebral metastasis were enrolled and allocated,using a random number table,to a study group and a control group,with 54 cases in each group.The control group received oral administration of Oxycodone Hydrochloride sustained release tablets and the study group received acupuncture in addition.The relieving effects on pain were compared between the two groups.Depression and anxiety severities were assessed using the self-rating depression scale(SDS)and the self-rating anxiety scale(SAS)respectively.The quality of life was assessed using the quality of life scale(QLS)in the two groups of patients before and after treatment.The toxic and side effect on the digestive system was observed in the two groups.Result The total pain relief rate was significantly higher in the study group than that in the control group with a statistically significant difference(P<0.05).After treatment,the SAS,SDS and NRS scores decreased in the two groups compared with before(P<0.05)and were lower in the study group than those in the control group(P<0.05).After treatment,the rate of good quality of life and the QLS total score were significantly higher in the study group than those in the control group with statistically significant differences between the two groups(P<0.05).There was no statistically significant difference in the incidence of adverse reactions in the digestive system between the two groups(P>0.05).Conclusion Acupuncture plus Oxycodone Hydrochloride sustained release tablets as adjuvant treatment for severe cancer pain caused by vertebral metastasis can effectively alleviate the pain,relieve depression and anxiety and improve the quality of life in the patients.
作者
陈卓
肖宏宇
程祺
CHEN Zhuo;XIAO Hong-yu;CHENG Qi(Jilin Cancer Hospital,Changchun 130012,China)
出处
《上海针灸杂志》
2021年第4期411-415,共5页
Shanghai Journal of Acupuncture and Moxibustion
基金
吉林省中医药科技项目(2019207)。
关键词
针刺疗法
针药并用
癌性疼痛
镇痛
疼痛强度
肿瘤转移
Acupuncture therapy
Acupuncture medication combined
Cancer pain
Analgesia
Pain severity
Tumor metastasis
