摘要
目的分析β-内酰胺类抗菌药物致严重药品不良反应的类型及临床表现,为临床安全用药提供参考。方法回顾性分析四川省德阳市第二人民医院2018-2019年由β-内酰胺类抗菌药物引起的严重药品不良反应的发生时间、症状、转归及可能的机制。结果β-内酰胺类抗菌药物引发的严重药品不良反应主要是过敏反应及过敏引起的一系列症状,用药2 h内发生的速发型过敏反应的严重程度高于迟发型过敏反应,经过积极治疗,8例患者均痊愈或好转。结论临床医务人员要熟悉β-内酰胺类抗菌药物的常见不良反应和救治措施,详细询问过敏史,按规定进行皮试,用药期间注意观察,一旦发生严重药品不良反应立即救治。
Objective To analyse the types and clinical manifestations of serious adverse drug reactions caused byβ-lactam antibiotics,and provide some references for clinical drug use.Methods Retrospectively analysed the occurrence time,symptoms,outcome and possible mechanism of serious adverse drug reactions caused byβ-lactams in the Second People’s Hospital of Deyang City,Sichuan Province from 2018 to 2019.Results Serious adverse reactions caused byβ-lactam antibiotics were mainly allergic reactions and a series of symptoms caused by allergic reactions,and all of them recovered or improved after active treatment.The severity of anaphylaxis within 2 hours was higher than that of delayed anaphylaxis.Conclusion Clinical staff should be familiar with the common adverse reactions and treatment measures ofβ-lactam antibiotics,inquire allergic history in medicine in detail,carry out skin test according to regulations,and pay attention to observation during medication,and immediately organize the rescue and medical treatment when adverse drug reactions occur.
作者
张奇兵
袁珺
ZHANG Qibing;YUAN Jun(Dept,of Pharmacy,The Second People's Hospital of Deyang City,Sichuan Province,Deyang 618000,China)
出处
《临床合理用药杂志》
2021年第7期4-6,共3页
Chinese Journal of Clinical Rational Drug Use
