摘要
microRNAs在表观遗传学中的作用已被明确,目前在双相情感障碍患者死后的脑组织中及外周循环中均发现microRNAs的表达较正常存在差异,其有望成为一种可靠的生物学标记物进而提供一种更准确、快捷的诊断方式。部分用于治疗双相情感障碍的药物被认为可能是通过改变脑组织中microRNAs的表达起作用,基于此研发的新药有望改善双相情感障碍患者的预后,促进患者社会功能的恢复,减轻社会负担。为进一步了解双相情感障碍神经生物学机制并为未来的相关研究及诊疗提供新思路,本文对microRNAs在双相情感障碍中作用机制的研究进行了综述。
In order to further understand the neurobiological mechanism of bipolar disorder and provide new ideas for future researches,diagnosis and treatment,this paper reviews the research on the mechanism of microRNAs in bipolar disorder.The role of microRNAs in epigenetics has been well established.At present,microRNAs are found to have different expressions from normal ones in brain tissues and peripheral circulation of patients with bipolar disorder,which is expected to be a reliable biological marker,and provide a more accurate and rapid diagnostic method.Some of the drugs used to treat bipolar disorder have been shown to work by changing the expression of microRNAs in brain tissue.Based on this,the new drugs are expected to improve the prognosis of patients with bipolar disorder,promote the recovery of social functions of patients,and reduce the social burden.
作者
王海明
杨康
张跃坤
佟靓
吴昊
赵青枫
Wang Haiming;Yang Kang;Zhang Yuekun(The Mental Health Center Affiliated to Kunming Medical University,The Mentel Hospital of Yunnan Province,Kunming,Yunnan650224)
出处
《基层医学论坛》
2021年第11期1588-1591,共4页
The Medical Forum
基金
昆明市卫生科技人才培养项目暨“十百千”工程(2018-SW(后备)-103)
昆明市卫生健康委员会卫生科研课题项目(2020-03-09-113)。
