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芪血通络片辅助治疗糖尿病足溃疡的临床疗效 被引量:3

Clinical effect of Qixue Tongluo Tablets in adjuvant treatment of diabetic foot ulcer
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摘要 目的分析芪血通络片辅助治疗糖尿病足溃疡的临床疗效及安全性。方法选择2019年1月—2020年1月辽宁中医药大学附属医院收治的124例糖尿病足溃疡患者作为研究对象,采用抽签方法将患者分成对照组(62例)与观察组(62例)。对照组患者均给予血糖控制、抗感染、机体微循环改善等综合治疗。观察组在对照组基础上口服芪血通络片,4片/次,3次/d。所有患者均治疗2个月。观察两组患者的临床疗效,同时比较两组治疗前后的病足溃疡大小、糖代谢指标(包括空腹血糖、餐后2 h血糖、糖化血红蛋白)以及炎症指标(白细胞计数、超敏C-反应蛋白、D-葡聚糖)等的变化情况。结果治疗后,对照组和观察组总有效率分别为69.36%和85.48%,两组对比差异有统计学意义(P<0.05)。治疗后,两组患者的病足溃疡长径、短径均显著缩短,差异有统计学意义(P<0.05);且观察组患者的病足溃疡长径、短径均显著短于对照组,两组对比差异有统计学意义(P<0.05)。治疗后,两组空腹血糖、餐后2 h血糖、糖化血红蛋白、白细胞计数、超敏C-反应蛋白、D-葡聚糖均较治疗前显著降低,差异有统计学意义(P<0.05);且观察组的上述指标水平均显著低于对照组,对比差异有统计学意义(P<0.05)。两组均未发生严重不良反应。结论芪血通络片辅助治疗糖尿病足疗效显著,能显著缩小患者的溃疡面积,控制患者血糖,改善患者炎症症状,同时引发不良反应少,安全性高,值得推荐。 Objective To analyze the efficacy and safety of Qixue Tongluo Tablets in treatment of diabetic foot ulcer.Methods A total of 124 patients with diabetic foot ulcer admitted to Affiliated Hospital of Liaoning University of Traditional Chinese Medicine from January 2019 to January 2020 were selected as the research subjects.The patients were divided into control group(62 cases)and observation group(62 cases)by lotting.Patients in the control group were given integrated treatment of blood glucose control,anti-infection and microcirculation improvement.Patients in the observation group were po administered with Qixue Tongluo Tablets on the basis of control,4 tablets/time,three times daily.All patients were treated for 2 months.The clinical efficacy of two groups was observed,and the changes in the size of foot ulcer,glucose metabolism indexes(including fasting blood glucose,blood glucose at 2 h postprandial,glycosylated hemoglobin)and inflammatory indexes(WBC count,hypersensitive C-reactive protein,Dglucan)before and after treatment were compared between two groups.Results After treatment,the total effective rate of the control group and the observation group was 69.36%and 85.48%,respectively,and there was statistical significance between two groups(P<0.05).After treatment,the length diameter and short diameter of diseased foot ulcer in two groups were significantly shortened,with statistical significance(P<0.05).The length diameter and short diameter of diseased foot ulcer in the observation group were significantly shorter than those in the control group,and the difference between the two groups was statistically significant(P<0.05).After treatment,fasting blood glucose,2 h postprandial blood glucose,glycated hemoglobin,white blood cell count,hypersensitive C-reactive protein,and D-glucan in two groups were significantly decreased compared with before treatment,with statistical significance(P<0.05).The above indexes in the observation group were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).No serious adverse reactions occurred in both groups.Conclusion Qixue Tongluo Tablets has significant efficacy in adjuvant treatment of diabetic foot,which can significantly reduce the ulcer area,control the blood sugar of patients,improve the inflammatory symptoms of patients,and cause fewer adverse reactions,with high safety,and is worthy of recommendation.
作者 于锡安 李大勇 YU Xi'an;LI Dayong(Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China;Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110000,China)
出处 《药物评价研究》 CAS 2021年第3期594-597,共4页 Drug Evaluation Research
关键词 芪血通络片 空腹血糖 餐后2 h血糖 糖化血红蛋白 白细胞计数 超敏C-反应蛋白 D-葡聚糖 Qixue Tongluo Tablets fasting blood glucose blood glucose at 2 h postprandial glycosylated hemoglobin white blood cell count hypersensitive C-reactive protein D-glucan
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