摘要
Ames试验是一项体外致突变性试验,被广泛用于药物、食品、化学品和农药的遗传毒性检测,以评价受试物致突变的可能性。药物、食品、化学品和农药的指导原则和国家标准中Ames试验方法不尽相同,就这几者Ames试验方法的主要异同点进行比较分析,以期能熟练掌握Ames试验实施要点,更加规范实施检测工作,不断提高试验质量。
Ames test is a mutagenicity test in vitro, which is widely used in the detection of genotoxicity of drugs, food, chemicals and pesticides to evaluate the possibility of mutagenicity of test substance. The guiding principles and national standards of Ames test on drugs, food, chemicals and pesticidesand are different. In this paper, the main similarities and differences were compared and analyzed in order to master the key points of Ames test implementation, so we can implement the testing work standardly and improve the test quality constantly.
作者
高梅
曹冲
王功霞
马会
英永
GAO Mei;CAO Chong;WANG Gongxia;MA Hui;YING Yong(Shandong Academy of Pharmaceutical Sciences,Shandong Provincial Key Laboratory of Chemical Drug,Jinan 250101,China;Shandong Normal University,College of Life Sciences,Shandong Provincial Key Laboratory of Animal Resistance Biology,Jinan 250014,China)
出处
《药物评价研究》
CAS
2021年第3期672-676,共5页
Drug Evaluation Research
基金
山东省创新公共服务平台项目(2015CXPT00001)。
