摘要
目的探讨新型冠状病毒肺炎(NCP)患者不同热型与免疫功能之间的关系。方法回顾性分析宁夏地区确诊83例NCP患者临床资料,分析NCP患者不同热型与临床指标及免疫功能的差异。结果从无发热组、低热组到高热组,患者存在年龄增加、住院天数延长、入院生命体征(体温、心率、经皮血氧饱和度)差、72 h胸部影像加重等的趋势(P<0.05)。无发热组和低热组患者以轻型和普通型为主,危重症患者全部来自高热组。从无发热组、低热组至高热组,存在淋巴细胞总数下降(入院后第3、7天)、淋巴细胞百分比降低(出院日)、C反应蛋白升高等的趋势(P<0.05)。从无发热组、低热组至高热组,总T淋巴细胞百分比、抑制/细胞毒T淋巴细胞百分比、淋巴细胞绝对数目、总T淋巴细胞绝对数目、辅助/诱导T淋巴细胞绝对数目、抑制/细胞毒T淋巴细胞绝对数目等指标呈整体递减趋势改变。其中,抑制/细胞毒T淋巴细胞百分比(入院后第3、7天)、辅助/抑制T淋巴细胞比值(入院后第7天)、总T淋巴细胞绝对数目(入院后第3天)、抑制/细胞毒T淋巴细胞绝对数目(入院后第7天)等指标比较差异有统计学意义(P<0.05)。结论NCP患者的发热程度与病情的严重程度存在关联性,发热程度越高者,细胞免疫抑制表现也越重,是进展为危重症型的关键或危险环节。
Objective To explore the relationships between different fever types and immune function in patients with COVID-19.Methods The clinical data of 83 patients with NCP were analyzed retrospectively.The heat types,clinical index and immune function in NCP patients were analyzed.Results From the non-fever group to the low-fever group and the high-fever group,the patients showed some trends of increasing age,prolonged hospitalization days,poor admission vital signs(body temperature,heart rate,SPO 2),and the aggravation of chest imaging at 72 hours(P<0.05).The patients in non-fever Group and low fever group were mainly mild and ordinary type,while the critical patients were all from the high-fever group.The total number of lymphocytes(on the 3rd and 7th day after admission)and percentage of lymphocytes decreased(on the day of discharge),and C-reactive protein increased from no fever to low fever and high fever group(P<0.05).From no fever group to low fever group and high fever group,the percentage of T lymphocyte,the percentage of inhibiting/cytotoxic T lymphocyte,the absolute number of lymphocyte,the absolute number of lymphocyte,the absolute number of lymphocyte and the absolute number of lymphocyte were all decreased.There were statistically significant differences in the percentage of inhibitory/cytotoxic T lymphocytes(on the 3rd and 7th day after admission),the ratio of helper/inhibitory T lymphocytes(on the 7th day after admission),the absolute number of total T lymphocytes(on the 3rd day after admission),and the absolute number of inhibitory/cytotoxic T lymphocytes(on the 7th day after admission).Conclusion The degree of fever in NCP patients is related to the severity of the disease.The higher the degree of fever is,the more severe in state of illness with the cellular immunosuppression is.The degree of fever is the key or dangerous link in the progression of NCP.
作者
冯涛
魏建华
高小芳
王晓麒
徐麟
周玮
郑西卫
赵桂霞
曹相原
FENG Tao;WEI Jianhua;GAO Xiaofang;WANG Xiaoqi;XU Lin;ZHOU Wei;ZHENG Xiwei;ZHAO Guixia;CAO Xiangyuan(The Third People's Hospital of Ningxia,Yinchuan 750011,China;The Forth People's Hospital of Ningxia,Yinchuan 750021,China;People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China;General Hospital of Nignxia Medical Univesity,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2021年第4期314-317,共4页
Ningxia Medical Journal
基金
宁夏回族自治区新冠肺炎疫情防控专项基金(2020BEG03061)。
关键词
新型冠状病毒肺炎
T淋巴细胞亚群
体液免疫
Novel coronavirus pneumonia
T lymphocyte cell subsets
Humoral immunity
