摘要
目的探讨细胞因子诱导的凋亡抑制因子1(CIAPIN1)和P糖蛋白(P-gp)蛋白在胃癌组织中的表达,分析二者对胃癌诊断的临床意义。方法回顾性分析2017年8月至2019年3月于本院行手术切除治疗的60例胃癌患者的临床资料,分析CIAPIN1、P-gp蛋白在胃癌及癌旁组织中的阳性率,分析临床分期、淋巴结转移情况对胃癌组织CIAPIN1、P-gp蛋白表达的影响。结果CIAPIN1、P-gp蛋白在胃癌组织中的阳性率高于癌旁组织,差异有统计学意义(P<0.05);临床分期Ⅲ~Ⅳ期患者胃癌组织CIAPIN1、P-gp阳性率高于Ⅰ~Ⅱ期,淋巴结转移患者胃癌组织CIAPIN1、P-gp阳性率高于未转移,差异有统计学意义(P<0.05);经线性回归分析检验显示,CIAPIN1、P-gp蛋白与胃癌临床分期、淋巴结转移相关(P<0.05)。结论CIAPIN1、P-gp蛋白在胃癌组织与癌旁组织表达存在差异,其表达与临床分期、淋巴结转移情况相关,CIAPIN1、P-gp蛋白表达对临床分期、淋巴结转移的诊断具有一定意义。
Objective To investigate the expression of cytokine-induced apoptosis inhibitor factor 1(CIAPIN1)and P-glycoprotein(P-gp)proteins in gastric cancer tissues and to analyze the clinical significance in the diagnosis of gastric cancer.Methods The clinical data of 60 patients with gastric cancer who underwent surgical resection in our hospital from August 2017 to March 2019 were retrospectively analyzed.The positive rates of CIAPIN1 and P-gp proteins in gastric cancer tissues and adjacent tissues were analyzed,and clinical stages were analyzed.The effect of lymph node metastasis on the expression of CIAPIN1 and P-gp protein in gastric cancer tissues.Results The positive rate of CIAPIN1 and P-gp protein in gastric cancer tissues were higher than that in adjacent tissues,and the difference was statistically significant(P<0.05).The positive rates of CIAPIN1 and P-gp in gastric cancer tissues in patients with clinical stageⅢ-Ⅳwere higher than stageⅠ-Ⅱ.The positive rate of CIAPIN1 and P-gp in gastric cancer tissues of patients with lymph node metastasis were higher than that of non-metastatic,and the difference was statistically significant(P<0.05).The linear regression analysis showed that CIAPIN1 and P-gp proteins were related to clinical stage Lymph node metastasis was related(P<0.05).Conclusion The expressions of CIAPIN1 and P-gp proteins are different in gastric cancer tissues and adjacent tissues.The expressions of CIAPIN1 and P-gp proteins are related to clinical stage and lymph node metastasis.The expression of CIAPIN1 and P-gp proteins is certain significance for the diagnosis of clinical stage and lymph node metastasis.
作者
姚军
YAO Jun(Department of Pathology,Zibo Traditional Chinese Medicine Hospital of Shandong Province,Zibo,Shandong,255300,China)
出处
《当代医学》
2021年第13期92-94,共3页
Contemporary Medicine
