摘要
近年来,诸多报道表明致癌信号通路与代谢活动间存在密切联系,因此,研究者们开始认识到代谢重编程在肿瘤中的重要性。在肿瘤发生发展的过程中,乳腺肿瘤细胞经历代谢重编程,包括增强的糖酵解、三羧酸循环、谷氨酰胺分解和脂肪酸生物合成过程,然而不同亚型之间的代谢重编程会有所差异。此外,乳腺肿瘤细胞的代谢改变重塑了肿瘤的微环境,例如促进了肿瘤的血管形成和抑制机体的免疫防御机制,进而加速了肿瘤的进展。对当前乳腺癌代谢重编程以及微环境重塑的研究进展进行综述,能够为开发各乳腺癌亚型的代谢靶向药物提供一定理论依据。
As numerous connections between oncogenic signalling pathways and metabolic activities emerge,the importance of metabolic reprogramming in cancer is being increasingly recognized.During tumorigenesis,breast cancer cells undergo metabolic reprogramming,which generally includes enhanced glycolysis,tricarboxylic acid cycle activity,glutaminolysis and fatty acid biosynthesis.The extension and functional importance of these metabolic alterations may diverge according to breast cancer subtypes.Besides,aberrant metabolism of breast cancer cells remodels tumor microenvironment,promoting cancer vascularization and inhibiting anti-tumor immu⁃nity,and thus accelerates tumor progression.This review addresses current knowledge on the metabolic repro⁃gramming and breast cancer microenvironment,which provides some reference for the development of metabolic target drugs for each breast cancer subtype.
作者
钱思嘉
尹骏
姚文兵
高向东
QIAN Sijia;YIN Jun;YAO Wenbing;GAO Xiangdong(Jiangsu Key Laboratory of Druggability of Biopharmaceuticals,China Pharmaceutical University,Nanjing 210009;School of Life Science and Technology,China Pharmaceutical University,Nanjing 210009,China)
出处
《中国药科大学学报》
CAS
CSCD
北大核心
2021年第2期156-163,共8页
Journal of China Pharmaceutical University
基金
中国药科大学“双一流”学科创新团队资助项目(No.CPU2018GF08)。
关键词
乳腺癌
细胞代谢
重编程
肿瘤微环境
进展
breast cancer
cell metabolism
reprogramming
tumor microenvironment
advance
