摘要
目的:运用网络药理学方法探讨药用昆虫琵琶甲中酚类成分潜在的药理作用及机制。方法:通过文献检索搜集琵琶甲主要酚类成分,运用PharmMapper平台预测酚类成分的潜在作用靶点,借助String数据库构建PPI网络,通过MAS 3.0数据库和KEGG数据库进行通路注释分析,采用Cytoscape软件构建成分—靶点—通路网络模型。结果:筛选出25个琵琶甲主要酚类成分,其潜在主要作用靶点121个,通过干预胰岛素信号通路、嘌呤代谢、黏着斑、VEGF、PPAR、MAPK等72条通路,发挥抗癌、抗炎等多种疗效。结论:琵琶甲主要酚类成分对肿瘤、炎症、内分泌系统、神经系统等方面疾病有治疗作用,并呈现多成分、多靶点、多通路的系统性调节作用特点。
Objective To investigate the potential pharmacological effect and possible molecular mechanism of phenols in Blaps rynchopetera of medicinal insects by network pharmacology.Methods The main phenols in B.rynchopetera were collected by literature retrieval.This study predicted the potential targets of the main phenols in B.rynchopetera with help of PharmMapper platform.The protein-protein interaction(PPI)network was constructed and analyzed by String database.The pathway information was acquired from MAS 3.0 and KEGG databases.Cytoscape software was used to construct the ingredient-target-pathway network of active phenols in B.rynchopetera.Results Twenty-five active phenols of B.rynchopetera were selected from a large amount of literature.The major active phenols of B.rynchopetera play anti-inflammatory,anti-cancer and other pharmacological effects by regulating 121 targets and affecting in 72 important pathways,such as insulin signaling pathway,purine metabolism,focal adhesion,VEGF signaling pathway,PPAR signaling pathway,and MAPK signaling pathway.Conclusion It indicated that the main active phenols in B.rynchopetera may have therapeutic effect on diseases of cancer,inflammation,endocrine system,nervous system and so on.In this study,it reflects the multi-components,multi-targets and multiple pathway features of traditional Chinese medicine.
作者
罗建蓉
唐策
李轩豪
张艺
LUO Jianrong;TANG Ce;LI Xuanhao;ZHANG Yi(College of Pharmacy,Dali University,Dali 671000,China;Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《中国民族民间医药》
2021年第7期27-35,共9页
Chinese Journal of Ethnomedicine and Ethnopharmacy
基金
云南省地方本科高校(部分)基础研究联合专项(2017FH001-093)
大理大学创新团队项目(ZKLX2019107)。
关键词
药用昆虫
琵琶甲
酚类
网络药理学
靶点
信号通路
Medicinal Insects
Blaps Rynchopetera Fairmaire
Phenols
Network Pharmacology
Potential Target
Signaling Pathway
