摘要
目的探索托伐普坦片和呋塞米注射液治疗心力衰竭的临床疗效及安全性。方法120例心力衰竭患者,依据单双号随机化分为观察组与对照组,各60例。对照组采用呋塞米治疗,观察组采用托伐普坦片治疗。对比两组临床疗效、不良反应发生情况及脑钠素(BNP)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)水平。结果观察组治疗后BNP水平(415.63±9.68)ng/L低于对照组的(598.72±9.24)ng/L,差异具有统计学意义(P<0.05)。观察组总有效率98.33%高于对照组的76.67%,差异具有统计学意义(P<0.05)。观察组不良反应发生率3.33%低于对照组的21.67%,差异具有统计学意义(P<0.05)。治疗后,观察组LVEDD、LVESD、LVEF水平均优于对照组,差异具有统计学意义(P<0.05)。结论对心力衰竭患者实施托伐普坦片治疗效果显著,可提高治疗安全性。
Objective To investigate the clinical efficacy and safety of tolvaptan tablets and furosemide injection in the treatment of heart failure.Methods A total of 120 patients with heart failure were divided into observation group and control group according to odd-even number method,with 60 cases in each group.The control group was treated with furosemide,and the observation group was treated with tolvaptan tablets.The clinical efficacy,occurrence of adverse reactions,brain natriuretic peptide(BNP),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD),and left ventricular ejection fraction(LVEF)levels were compared between the two groups.Results After treatment,the BNP of the observation group was(415.63±9.68)ng/L,which was lower than(598.72±9.24)ng/L of the control group,and the difference was statistically significant(P<0.05).The total effective rate 98.33%of the observation group was higher than 76.67%of the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions3.33%of the observation group was higher than 21.67%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of LVEDD,LVESD and LVEF of the observation group were better than those of the control group,and the difference was statistically significant(P<0.05).Conclusion Tolvaptan tablets has remarkable effect in the treatment of patients with heart failure,and it can improve the treatment safety.
作者
崔国艳
CUI Guo-yan(Special Ward,Liaoyang Central Hospital,Liaoyang 111000,China)
出处
《中国现代药物应用》
2021年第8期91-93,共3页
Chinese Journal of Modern Drug Application
