摘要
目的探讨胃癌患者血清癌胚抗原(CEA)、胃癌相关抗原(MG-Ag)、碱性成纤维细胞生长因子(bFGF)表达水平与术后复发转移的相关性。方法选取2014年2月-2016年3月鄂州市中心医院收治的胃癌患者300例,收集患者临床资料,术后1周采集患者外周血检测血清CEA、MG-Ag、bFGF表达水平,出院后保持随访,记录术后复发转移等相关情况。结果300例患者中有9例失访,11例因非胃癌疾病死亡,复发性胃癌患者32例,未复发患者248例。复发组与非复发组年龄、性别、肿瘤直径、分化程度比较差异无统计学意义(P>0.05);术前、术后1周复发组患者血清CEA、MG-Ag、bFGF表达水平均显著高于未复发组(P<0.05);术后1周两组患者血清CEA、MG-Ag、bFGF表达水平显著低于术前(P<0.05)。Pearson相关分析显示,复发组血清CEA、MG-Ag、bFGF表达水平两两之间呈中等程度相关(P均<0.05);血清CEA、MG-Ag、bFGF表达水平与术后复发具有相关性(P均<0.05)。结论胃癌患者术后血清CEA、MG-Ag、bFGF表达水平显著降低,三者表达水平呈正相关,可作为术后复发转移预测的独立危险因素。
Objective To investigate the correlation between the expression levels of serum carcinoembryonic antigen(CEA),monoclonal gastric cancer antigen(MG-Ag),basic fibroblast growth factor(bFGF)and recurrence and metastasis in patients with gastric cancer.Methods The clinical data of 300 patients with gastric cancer who were admitted to the hospital between February 2014 and March 2016 were collected.The peripheral blood of the patients was collected at one week after surgery to detect the expression levels of serum CEA,MG-Ag and bFGF.All patients were followed up after surgery,and the situation of recurrence and metastasis was recorded.Results 9 of the 300 patients were lost to follow-up;11 died of non-gastric cancer diseases;32 patients had recurrent gastric cancer,and 248 patients did not have recurrence.There was no significant differences in age,gender,tumor diameter or differentiation degree between the recurrence group and the non-recurrence group(P>0.05).Levels of serum CEA,MG-Ag and bFGF in the recurrence group were significantly higher than those in the non-recurrence group before surgery and at one week after surgery(P<0.05).Levels of serum CEA,MG-Ag and bFGF in the two groups were significantly decreased at 1 week after surgery(P<0.05).Pearson correlation analysis showed that there was a moderate correlation among the expression levels of serum CEA,MG-Ag and bFGF(P<0.05).The expression levels of serum CEA,MG-Ag and bFGF were correlated with postoperative recurrence(P<0.05).Conclusions The expression levels of serum CEA,MG-Ag and bFGF were significantly reduced in patients with gastric cancer,and these three parameters were positively correlated.They could be used as independent risk factors for predicting postoperative recurrence and metastasis.
作者
胡中保
陈敬生
孟平
李明
金军
HU Zhong-bao;CHEN Jing-sheng;MENG Ping;LI Ming;JIN Jun(Department of Oncology,E'zhou Central Hospital,E'zhou,E'zhou,Hubei 436000,China)
出处
《热带医学杂志》
CAS
2021年第2期197-200,共4页
Journal of Tropical Medicine
基金
湖北省卫生健康委员会联合基金项目(WJ2019H132)。
关键词
胃癌
癌胚抗原
胃癌相关抗原
碱性成纤维细胞生长因子
复发
Gastric cancer
Carcinoembryonic antigen
Gastric cancer antigen
Basic fibroblast growth factor
Recurrence
