摘要
随着社会人口逐渐步入老龄化,骨质疏松症(OP)的发病率逐年升高。而由于社会压力的增加和生活方式的改变,人们的睡眠问题也越来越显现。目前有研究表明二者间存在相关性。睡眠异常导致的褪黑素、糖皮质激素分泌水平的变化,IL-6、TNF-α等炎症因子浓度升高,Bmal1、Clock等时钟基因表达变化以及氧化应激反应的发生等会影响骨代谢,降低骨密度,甚至引发骨质疏松症。本文从昼夜节律紊乱,睡眠时间改变,睡眠呼吸暂停和睡眠用药四个角度出发,对近年来睡眠与OP症的相关性做一综述,并探讨各种睡眠问题与骨质疏松症间相关联的可能机制。
As the social population gradually ages,the incidence of osteoporosis increases year by year.Due to the increasing social pressure and changes in lifestyle,people’s sleeping problems are becoming more and more obvious.Current research shows that there is a correlation between the two.Changes in secretion levels of melatonin and glucocorticoids caused by abnormal sleeping,increased concentrations of inflammatory factors such as IL-6 and TNF-α,changes in the expression of clock genes such as Bmall and Clock,and the occurrence of oxidative stress,can affect bone metabolism,reduce bone mineral density,and even cause osteoporosis.This article reviews the relationship between sleep and osteoporosis in recent years from four perspectives:circadian rhythm disturbance,sleep time change,sleep apnea and sleep medication,and explores the possible correlative mechanism between various sleep problems and osteoporosis.
作者
贾易臻
谷福顺
王爱国
JIA Yizhen;GU Fushun;WANG Aiguo(Graduate School of Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300250, China)
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2021年第3期463-468,共6页
Chinese Journal of Osteoporosis
基金
天津市教委科研项目(2018KJ029)。
