摘要
瘙痒是特应性皮炎(AD)最为突出的临床症状,呈现出显著的昼夜节律性,以夜间瘙痒加重为主,治疗夜间瘙痒是控制AD的重要基础。生物钟是指在生理或行为上所表现的以约24 h为周期的生物节律,目前许多研究表明生物钟与AD夜间瘙痒加重密切相关。这些研究提示生物钟基因可通过调控ST2受体表达,诱导白细胞介素-33活化肥大细胞,在皮肤屏障功能、激素分泌水平、肥大细胞活化、炎症介质释放等方面均起到了重要的调节作用,而不仅仅是一个简单的时间概念。本综述旨在了解与时辰相关的过敏生物学,为治疗临床上难治的AD夜间瘙痒提供新的思路。
Pruritus is the most prominent clinical symptom of atopic dermatitis(AD),presenting a significant circadian rhythm,with the aggravation of nocturnal pruritus.The treatment of nocturnal pruritus is an important basis for the control of AD.Biological clock is a biological rhythm with a cycle of about 24 h in physiology or behavior.At present,many studies have shown that the clock is closely related to the aggravation of nocturnal pruritus in AD.These studies suggest that clock gene can induce interleukin-33 to activate mast cells by regulating the expression of ST2 receptor,which plays an important role in regulating skin barrier function,hormone secretion level,mast cell activation and inflammatory mediators release,rather than a simple concept of time.This review aims to understand the biology of allergy related to time,and provide new ideas for the treatment of clinically refractory AD at nocturnal pruritus.
作者
王怡沁
马欣
王东明
张慧敏
WANG Yiqin;MA Xin;WANG Dongming;ZHANG Huimin(Department of Dermatology,Shanghai University of Traditional Chinese Medicine Shuguang Hospital,Shanghai201210,China)
出处
《中国医药导报》
CAS
2021年第11期33-36,共4页
China Medical Herald
基金
国家自然科学基金资助项目(81974570)。
