摘要
探讨复方丹参滴丸联合氯吡格雷对冠心病心绞痛的临床疗效及对血清白细胞介素6(IL-6)及白细胞介素10(IL-10)水平的影响。将2017年8月至2019年5月期间该院收治的84例冠心病心绞痛患者按随机数表法分为对照组(n=42)与观察组(n=42)。对照组给予氯吡格雷片治疗,观察组给予复方丹参滴丸联合氯吡格雷片治疗,对比两组临床疗效、临床症状、硝酸甘油含服量、血液流变学相关指标及IL-6、IL-10的变化情况。观察组治疗总有效率与对照组相比更高(95.24%vs 76.19%),差异具有统计学意义(P<0.05);治疗4 w后,两组患者发作频率、持续时间、硝酸甘油含服量、血液黏度、FIB、MPA、HCT、IL-6及IL-10等指标均有所降低,且观察组相比对对照组降低的幅度更大,两组患者对比差异较显著(P<0.05)。采用复方丹参滴丸联合氯吡格雷治疗冠心病心绞痛疗效确切,可有效控制病情发作,同时降低血液流变学相关指标与IL-6、IL-10水平,具有进一步应用价值。
To explore the clinical effect of Compound Danshen dropping pill and clopidogrel on angina pectoris of coronary heart disease and its effect on the levels of IL-6 and IL-10,from August 2017 to May 2019,84 patients with angina pectoris were randomly divided into control group( n = 42) and observation group( n = 42). The control group was treated with clopidogrel tablets,and the observation group was treated with Compound Danshen dropping pills and clopidogrel tablets. The total effective rates of the observation group were higher than those of the control group( 95.24% vs 76.19%),and the difference was statistically significant( P<0.05).After 4 weeks of treatment,the attack frequency,duration,nitroglycerin content,blood viscosity,FIB,MPA,HCT,IL-6 and IL-10 and other indicators of the two groups were all reduced,and the observation group was compared with the control group.The rate of decrease in the group was greater,and the difference between the two groups of patients was significant( P < 0. 05).Compound Danshen dropping pill combined with clopidogrel were effective in the treatment of angina pectoris of coronary heart disease.It could effectively control the attack of the disease and reduced the indexes related to hemorheology and IL-6 and IL-10.It was worthy of further application.
作者
张晶
周慧瑾
ZHANG Jing;ZHOU Hui-Jin(Department of Pharmacy,Beijing Century Tan Hospital,Capital Medical University,Beijing 100038,China;Department of Anesthesiology,the Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine,Beijing 100029,China)
出处
《药物生物技术》
CAS
2021年第1期70-73,共4页
Pharmaceutical Biotechnology
关键词
复方丹参滴丸
氯吡格雷
冠心病心绞痛
临床疗效
Compound danshen dropping pill
Clopidogrel
Angina pectoris of coronary heart disease
Clinical effect
