摘要
目的探讨BICE患儿血清和脑脊液IL-6及MMP-9水平变化的临床价值。方法选取首次住院的42例BICE患儿为观察组,将其按惊厥发生次数再分为2组。另选同期住院的42例轻度胃肠炎患儿为对照组。检测各组患儿血清和脑脊液IL-6和MMP-9水平。结果观察组急性期血清和脑脊液中IL-6和MMP-9水平均显著高于对照组(t=8.56~13.71,P<0.01),观察组2二者水平均高于观察组1(t=10.80~37.40,P<0.01);两观察组恢复期血清中IL-6和MMP-9水平较急性期均显著降低,但观察组1降低幅度大于观察组2(P<0.05)。结论结论BICE患儿血清和脑脊液IL-6及MMP-9水平变化能反映其脑损伤程度,为临床诊疗提供依据。
Objective To investigate the clinical value of serum and cerebrospinal fluid IL-6 and MMP-9 levels in children with BICE.Methods A total of 42 children with BICE who were hospitalized for the first time were selected as the observation group,and they were divided into 2 groups according to the number of convulsions.Another 42 children with mild gastroenteritis who were hospitalized during the same period were selected as the control group.The levels of IL-6 and MMP-9 in serum and cerebrospinal fluid of children in each group were detected.Results The levels of IL-6 and MMP-9 in serum and cerebrospinal fluid in the observation groups were significantly higher than those in the control group(t=8.56-13.71,P<0.01),and the levels of the two in Observation Group 2 were higher than those in Observation Group 1(t=10.80-37.40,P<0.01).The serum levels of IL-6 and MMP-9 in the two observation groups during the recovery period were significantly lower than those in the acute phase,but the reduction in Observation Group 1 was greater than that in Observation Group 2(P<0.05).Conclusion The changes in serum and cerebrospinal fluid IL-6 and MMP-9 levels in children with BICE can reflect the degree of brain damage and provide a basis for clinical diagnosis and treatment.
作者
徐丽云
王均林
王淑丽
李玉芬
XU Li-yun;WANG Jun-lin;WANG Shu-li;LI Yu-fen(Shandong Medical College,Linyi 276000,China;Linyi People's Hospital)
出处
《山东医学高等专科学校学报》
2021年第3期208-210,共3页
Journal of Shandong Medical College
