摘要
目的探讨中国西北地区年轻女性乳腺癌患者(<40岁)的临床病理特征和分子分型及其关系,为临床诊治提供理论依据。方法选取2001年1月至2012年6月在西安交通大学第一附属医院新确诊为乳腺癌且年龄<40岁的214例女性乳腺癌患者,对所有患者的临床病理特征及分子分型进行分析。结果 214例年轻女性乳腺癌患者中位年龄36岁,肿瘤直径(2.89±1.65)cm;luminal A 66例(30.84%),luminal B 77例(35.98%),Her2过表达30例(14.02%),三阴性41例(19.16%)。其中,60.75%的患者肿瘤直径>2 cm,62.15%的患者肿瘤分级为3级,75.70%的患者临床分期为Ⅱ、Ⅲ期。不同分子分型患者的肿瘤直径、临床分期、肿瘤分级及Ki67表达情况比较,差异具有统计学意义(P<0.05)。<30岁与30~<40岁患者的肿瘤分级比较,差异具有统计学意义(P<0.05)。luminal A和luminal B与Her2过表达患者的疾病无进展生存期(PFS)比较,差异具有统计学意义(P<0.05)。结论年轻乳腺癌患者的临床病理特征在分子分型方面具有差异,且分子分型影响预后,而关于年轻女性乳腺癌患者不同分子分型下肿瘤增殖情况及影响其预后的分子机制有待进一步研究。
Objective To explore the clinicopathological features,molecular types and their relationship of young women with breast cancer(<40 years old)in northwest China,and to provide theoretical basis for clinical diagnosis and treatment.Methods A total of 214 women patients with breast cancer who were newly diagnosed as breast cancer and aged<40 years old in the first affiliated hospital of Xi'an jiaotong university were selected from January 2001 to June 2012.The clinicopathological features and molecular types of all patients were analyzed.Results The median age of 214 young women patients with breast cancer was 36 years old,the diameter of tumor was(2.89±1.65)cm;66 cases(30.84%)was luminal A,77 cases(35.98%)was luminal B,30 cases(14.02%)was Her2 over expression,41 cases(19.16%)was triple negative.Among them,60.75%of the patients had tumor diameter>2 cm,62.15%of the patients were classified as grade 3,clinical stage of 75.70%patients were phaseⅡand phaseⅢ.The differences of tumor diameter,clinical stage,tumor classification and Ki67 expression in different molecular types of patients were statistically significant(P<0.05).The differences in the tumor grades of patients between aged<30 and 30-<40 years was statistically significant(P<0.05).The differences in disease progression free survival(PFS)of patients between luminal A,luminal B and Her2 over expressed were statistically significant(P<0.05).Conclusion The clinicapathological features of young breast cancer patients are different in molecular types,and the molecular types affects prognosis.However,the tumor proliferation and molecular mechanism affecting the prognosis of young women breast cancer patients under different molecular types needs further study.
作者
程婷婷
安家祯
吕美玲
杨谨
CHENG Tingting;AN Jiazhen;LYU Meiling;YANG Jin(Chang'an University Hospital,Xi'an 710064;Shaanxi Forest Industry Worker Hospital,Xi'an 710300;the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)
出处
《临床医学研究与实践》
2021年第13期25-28,共4页
Clinical Research and Practice
基金
西安交通大学第一附属医院临床研究项目(No.XJTU1AF-CRF-2016-020)。
关键词
年轻
女性乳腺癌
临床病理特征
分子分型
young
female breast cancer
clinicopathological features
molecular types
